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10.1111/jmp.12120

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suck abstract from ncbi


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pmid25379595
      J+Med+Primatol 2014 ; 43 (5 ): 370-3
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  • Preclinical evaluation of the immunomodulatory lymphocyte trafficking drug FTY720 for HIV prevention in the female genital mucosa of macaques #MMPMID25379595
  • Morris M ; Aubert RD ; Butler K ; Henning T ; Mitchell J ; Jenkins L ; Garber D ; McNicholl J ; Kersh EN
  • J Med Primatol 2014[Oct]; 43 (5 ): 370-3 PMID25379595 show ga
  • FTY720 has been shown to reduce inflammatory cytokines and immune cells in the genital mucosa of macaques. This pilot study examined the ability of FTY720 to inhibit HIV acquisition. Systemic treatment with FTY720 failed to prevent or delay vaginal SHIV transmission.
  • |*Macaca nemestrina [MESH]
  • |Administration, Intravaginal [MESH]
  • |Administration, Intravenous [MESH]
  • |Animals [MESH]
  • |Cervix Uteri/chemistry/*immunology [MESH]
  • |Drug Evaluation, Preclinical [MESH]
  • |Female [MESH]
  • |Fingolimod Hydrochloride [MESH]
  • |HIV Infections/prevention & control [MESH]
  • |Immunomodulation [MESH]
  • |Immunosuppressive Agents/*pharmacology [MESH]
  • |Lymphocytes/drug effects [MESH]
  • |Mucous Membrane/chemistry/immunology [MESH]
  • |Pilot Projects [MESH]
  • |Propylene Glycols/*pharmacology [MESH]
  • |Simian Acquired Immunodeficiency Syndrome/prevention & control [MESH]
  • |Simian Immunodeficiency Virus/*drug effects [MESH]
  • |Sphingosine/*analogs & derivatives/pharmacology [MESH]


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