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10.1016/j.neuron.2014.09.034 http://scihub22266oqcxt.onion/10.1016/j.neuron.2014.09.034 C4223653!4223653!25374355     free     free     free       Neuron 2014 ; 84 (2): 275-91 Nephropedia Template TP {{tp|p=25374355|t=2014. The Neurology of mTOR |pdf=|usr=}}{{25374355}} gab.com Text The Neurology of mTOR JO: Neuron http://www.kidney.de/pget.php?&tw=1&pmid=25374355 #FOAvip The mechanistic target of rapamycin (mTOR) signaling pathway is a crucial cellular signaling hub that, like the nervous system itself, integrates internal and external cues to elicit critical outputs including growth control, protein synthesis, gene expression, and metabolic balance. The importance of mTOR signaling to brain function is underscored by the myriad disorders in which mTOR pathway dysfunction is implicated, such as autism, epilepsy, and neurodegenerative disorders. Pharmacological manipulation of mTOR signaling holds therapeutic promise and has entered clinical trials for several disorders. Here, we review the functions of mTOR signaling in the normal and pathological brain, highlighting ongoing efforts to translate our understanding of cellular physiology into direct medical benefit for neurological disorders. Twit Text FOAVip The Neurology of mTOR ????Neuron http://www.kidney.de/pget.php?&tw=1&pmid=25374355 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25374355 #FOAvip English Wikipedia <ref>{{Cite pmid|25374355}}</ref> The Neurology of mTOR #MMPMID25374355 Lipton JO; Sahin M Neuron 2014[Oct]; 84 (2): 275-91 PMID25374355show ga The mechanistic target of rapamycin (mTOR) signaling pathway is a crucial cellular signaling hub that, like the nervous system itself, integrates internal and external cues to elicit critical outputs including growth control, protein synthesis, gene expression, and metabolic balance. The importance of mTOR signaling to brain function is underscored by the myriad disorders in which mTOR pathway dysfunction is implicated, such as autism, epilepsy, and neurodegenerative disorders. Pharmacological manipulation of mTOR signaling holds therapeutic promise and has entered clinical trials for several disorders. Here, we review the functions of mTOR signaling in the normal and pathological brain, highlighting ongoing efforts to translate our understanding of cellular physiology into direct medical benefit for neurological disorders. äThe Neurology of mTOR (epmc).pdf DeepDyve Pubget Overpricing