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10.1016/j.scr.2014.04.010

http://scihub22266oqcxt.onion/10.1016/j.scr.2014.04.010
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suck abstract from ncbi


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pmid24881775
      Stem+Cell+Res 2014 ; 13 (3 Pt B ): 571-81
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  • Harnessing Hippo in the heart: Hippo/Yap signaling and applications to heart regeneration and rejuvenation #MMPMID24881775
  • Lin Z ; Pu WT
  • Stem Cell Res 2014[Nov]; 13 (3 Pt B ): 571-81 PMID24881775 show ga
  • The adult mammalian heart exhibits limited regenerative capacity after myocardial injury, a shortcoming that is responsible for the current lack of definitive treatments for heart failure. A search for approaches that might enhance adult heart regeneration has led to interest in the Hippo/Yap signaling pathway, a recently discovered signaling pathway that regulates cell proliferation and organ growth. Here we provide a brief overview of the Hippo/Yap pathway and its known roles in the developing and adult heart. We discuss the implications of Hippo/Yap signaling for regulation of cardiomyocyte death and regeneration.
  • |*Regeneration [MESH]
  • |*Rejuvenation [MESH]
  • |Adaptor Proteins, Signal Transducing/genetics/*metabolism [MESH]
  • |Animals [MESH]
  • |Heart Diseases/*enzymology/genetics/metabolism/physiopathology/therapy [MESH]
  • |Heart/*physiopathology [MESH]
  • |Hippo Signaling Pathway [MESH]
  • |Humans [MESH]
  • |Myocytes, Cardiac/cytology/*enzymology/metabolism [MESH]
  • |Phosphoproteins/genetics/*metabolism [MESH]
  • |Protein Serine-Threonine Kinases/genetics/*metabolism [MESH]
  • |Signal Transduction [MESH]
  • |Transcription Factors [MESH]


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