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2014 ; 13
(3 Pt B
): 571-81
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gab.com Text
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Harnessing Hippo in the heart: Hippo/Yap signaling and applications to heart
regeneration and rejuvenation
#MMPMID24881775
Lin Z
; Pu WT
Stem Cell Res
2014[Nov]; 13
(3 Pt B
): 571-81
PMID24881775
show ga
The adult mammalian heart exhibits limited regenerative capacity after myocardial
injury, a shortcoming that is responsible for the current lack of definitive
treatments for heart failure. A search for approaches that might enhance adult
heart regeneration has led to interest in the Hippo/Yap signaling pathway, a
recently discovered signaling pathway that regulates cell proliferation and organ
growth. Here we provide a brief overview of the Hippo/Yap pathway and its known
roles in the developing and adult heart. We discuss the implications of Hippo/Yap
signaling for regulation of cardiomyocyte death and regeneration.
|*Regeneration
[MESH]
|*Rejuvenation
[MESH]
|Adaptor Proteins, Signal Transducing/genetics/*metabolism
[MESH]