Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25065585
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Arch+Biochem+Biophys
2014 ; 563
(ä): 60-70
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
The role of microRNAs and long non-coding RNAs in the pathology, diagnosis, and
management of melanoma
#MMPMID25065585
Aftab MN
; Dinger ME
; Perera RJ
Arch Biochem Biophys
2014[Dec]; 563
(ä): 60-70
PMID25065585
show ga
Melanoma is frequently lethal and its global incidence is steadily increasing.
Despite the rapid development of different modes of targeted treatment, durable
clinical responses remain elusive. A complete understanding of the molecular
mechanisms that drive melanomagenesis is required, both genetic and epigenetic,
in order to improve prevention, diagnosis, and treatment. There is increased
appreciation of the role of microRNAs (miRNAs) in melanoma biology, including in
proliferation, cell cycle, migration, invasion, and immune evasion. Data are also
emerging on the role of long non-coding RNAs (lncRNAs), such as SPRY4-IT1, BANCR,
and HOTAIR, in melanomagenesis. Here we review the data on the miRNAs and lncRNAs
implicated in melanoma biology. An overview of these studies will be useful for
providing insights into mechanisms of melanoma development and the miRNAs and
lncRNAs that might be useful biomarkers or future therapeutic targets.
|Animals
[MESH]
|Apoptosis
[MESH]
|Biomarkers, Tumor/genetics/metabolism
[MESH]
|Cell Cycle
[MESH]
|Cell Proliferation
[MESH]
|Epigenesis, Genetic
[MESH]
|Humans
[MESH]
|Immunity, Innate/genetics
[MESH]
|Melanocytes/metabolism
[MESH]
|Melanoma/diagnosis/*genetics/therapy
[MESH]
|MicroRNAs/*genetics/metabolism/therapeutic use
[MESH]