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10.1245/s10434-014-3888-y http://scihub22266oqcxt.onion/10.1245/s10434-014-3888-y C4221469!4221469 !25023548     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25023548 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Ann+Surg+Oncol 2014 ; 21 (13 ): 4164-73 Nephropedia Template TP {{tp|p=25023548 |t=2014. SMO expression in colorectal cancer: associations with clinical, pathological, and molecular features |pdf=|usr=}}{{25023548 }} gab.com Text SMO expression in colorectal cancer: associations with clinical, pathological, and molecular features JO: Ann Surg Oncol http://www.kidney.de/pget.php?&tw=1&pmid=25023548 #FOAvip BACKGROUND: Smoothened, frizzled family receptor (SMO) is an important component of the hedgehog signaling pathway, which has been implicated in various human carcinomas. However, clinical, molecular, and prognostic associations of SMO expression in colorectal cancer remain unclear. METHODS: Using a database of 735 colon and rectal cancers in the Nurse's Health Study and the Health Professionals Follow-up Study, we examined the relationship of tumor SMO expression (assessed by immunohistochemistry) to prognosis, and to clinical, pathological, and tumor molecular features, including mutations of KRAS, BRAF, and PIK3CA, microsatellite instability, CpG island methylator phenotype (CIMP), LINE-1 methylation, and expression of phosphorylated AKT and CTNNB1. RESULTS: SMO expression was detected in 370 tumors (50 %). In multivariate logistic regression analysis, SMO expression was independently inversely associated with phosphorylated AKT expression [odds ratio (OR) 0.48; 95 % confidence interval (CI) 0.34-0.67] and CTNNB1 nuclear localization (OR 0.48; 95 % CI 0.35-0.67). SMO expression was not significantly associated with colorectal cancer-specific or overall survival. However, in CIMP-high tumors, but not CIMP-low/0 tumors, SMO expression was significantly associated with better colorectal cancer-specific survival (log-rank P = 0.012; multivariate hazard ratio, 0.36; 95 % CI 0.13-0.95; P interaction = 0.035, for SMO and CIMP status). CONCLUSIONS: Our data reveal novel potential associations between the hedgehog, the WNT/CTNNB1, and the PI3K (phosphatidylinositol-4,5-bisphosphonate 3-kinase)/AKT pathways, supporting pivotal roles of SMO and hedgehog signaling in pathway networking. SMO expression in colorectal cancer may interact with tumor CIMP status to affect patient prognosis, although confirmation by future studies is needed. Twit Text FOAVip SMO expression in colorectal cancer: associations with clinical, pathological, and molecular features ????Ann Surg Oncol http://www.kidney.de/pget.php?&tw=1&pmid=25023548 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25023548 #FOAvip English Wikipedia <ref>{{Cite pmid|25023548 }}</ref> SMO expression in colorectal cancer: associations with clinical, pathological, and molecular features #MMPMID25023548 Li T ; Liao X ; Lochhead P ; Morikawa T ; Yamauchi M ; Nishihara R ; Inamura K ; Kim SA ; Mima K ; Sukawa Y ; Kuchiba A ; Imamura Y ; Baba Y ; Shima K ; Meyerhardt JA ; Chan AT ; Fuchs CS ; Ogino S ; Qian ZR Ann Surg Oncol 2014[Dec]; 21 (13 ): 4164-73 PMID25023548 show ga BACKGROUND: Smoothened, frizzled family receptor (SMO) is an important component of the hedgehog signaling pathway, which has been implicated in various human carcinomas. However, clinical, molecular, and prognostic associations of SMO expression in colorectal cancer remain unclear. METHODS: Using a database of 735 colon and rectal cancers in the Nurse's Health Study and the Health Professionals Follow-up Study, we examined the relationship of tumor SMO expression (assessed by immunohistochemistry) to prognosis, and to clinical, pathological, and tumor molecular features, including mutations of KRAS, BRAF, and PIK3CA, microsatellite instability, CpG island methylator phenotype (CIMP), LINE-1 methylation, and expression of phosphorylated AKT and CTNNB1. RESULTS: SMO expression was detected in 370 tumors (50 %). In multivariate logistic regression analysis, SMO expression was independently inversely associated with phosphorylated AKT expression [odds ratio (OR) 0.48; 95 % confidence interval (CI) 0.34-0.67] and CTNNB1 nuclear localization (OR 0.48; 95 % CI 0.35-0.67). SMO expression was not significantly associated with colorectal cancer-specific or overall survival. However, in CIMP-high tumors, but not CIMP-low/0 tumors, SMO expression was significantly associated with better colorectal cancer-specific survival (log-rank P = 0.012; multivariate hazard ratio, 0.36; 95 % CI 0.13-0.95; P interaction = 0.035, for SMO and CIMP status). CONCLUSIONS: Our data reveal novel potential associations between the hedgehog, the WNT/CTNNB1, and the PI3K (phosphatidylinositol-4,5-bisphosphonate 3-kinase)/AKT pathways, supporting pivotal roles of SMO and hedgehog signaling in pathway networking. SMO expression in colorectal cancer may interact with tumor CIMP status to affect patient prognosis, although confirmation by future studies is needed. |*Gene Expression Regulation, Neoplastic [MESH] |*Mutation [MESH] |Aged [MESH] |Biomarkers, Tumor/*genetics [MESH] |Class I Phosphatidylinositol 3-Kinases [MESH] |Colorectal Neoplasms/*genetics/metabolism/mortality/pathology [MESH] |Female [MESH] |Follow-Up Studies [MESH] |Hedgehog Proteins/genetics [MESH] |Humans [MESH] |Kaplan-Meier Estimate [MESH] |Male [MESH] |Microsatellite Instability [MESH] |Middle Aged [MESH] |Phenotype [MESH] |Phosphatidylinositol 3-Kinases/genetics [MESH] |Prognosis [MESH] |Prospective Studies [MESH] |Proto-Oncogene Proteins B-raf/genetics [MESH] |Proto-Oncogene Proteins c-akt/genetics [MESH] |Proto-Oncogene Proteins p21(ras) [MESH] |Proto-Oncogene Proteins/genetics [MESH] |Receptors, G-Protein-Coupled/*genetics [MESH] |Signal Transduction [MESH] |Smoothened Receptor [MESH] |United States [MESH] |beta Catenin/genetics [MESH]SMO expression in colorectal cancer: associations with clinical, patho(epmc).pdf DeepDyve Pubget Overpricing