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10.1016/j.abb.2014.07.023 http://scihub22266oqcxt.onion/10.1016/j.abb.2014.07.023 C4221383!4221383!25109840     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Arch+Biochem+Biophys 2014 ; ä (ä): 13-21 Nephropedia Template TP {{tp|p=25109840|t=2014. Developmental Pathways Activated in Melanocytes and Melanoma |pdf=|usr=}}{{25109840}} gab.com Text Developmental Pathways Activated in Melanocytes and Melanoma JO: Arch Biochem Biophys http://www.kidney.de/pget.php?&tw=1&pmid=25109840 #FOAvip Cutaneous malignant melanomas originate primarily within epidermal melanocytic cells. Melanoma cells share many characteristics with melanocyte precursors, suggesting that melanoma cells utilize the developmental programs of their normal counterpart for their own progression. The pigmentation system provides an advantageous model to assess survival pathway interactions in the melanocytic lineage, as genetic alterations controlling melanocyte development can be easily detectable by coat color phenotype that do not affect the viability of an animal. By integrating combinatorial gene knockout approaches, cell-based assays and immunohistochemical observations, recent studies have illustrated several genes and pathways that play important roles both in melanocyte specification and maintenance and in melanoma formation and progression. We are reviewing those genes and pathways to understand the connection between normal and cancerous development and to reveal therapeutic potential of targeting developmental pathways for melanoma therapy. Twit Text FOAVip Developmental Pathways Activated in Melanocytes and Melanoma ????Arch Biochem Biophys http://www.kidney.de/pget.php?&tw=1&pmid=25109840 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25109840 #FOAvip English Wikipedia <ref>{{Cite pmid|25109840}}</ref> Developmental Pathways Activated in Melanocytes and Melanoma #MMPMID25109840 Liu J; Fukunaga-Kalabis M; Li L; Herlyn M Arch Biochem Biophys 2014[Dec]; ä (ä): 13-21 PMID25109840show ga Cutaneous malignant melanomas originate primarily within epidermal melanocytic cells. Melanoma cells share many characteristics with melanocyte precursors, suggesting that melanoma cells utilize the developmental programs of their normal counterpart for their own progression. The pigmentation system provides an advantageous model to assess survival pathway interactions in the melanocytic lineage, as genetic alterations controlling melanocyte development can be easily detectable by coat color phenotype that do not affect the viability of an animal. By integrating combinatorial gene knockout approaches, cell-based assays and immunohistochemical observations, recent studies have illustrated several genes and pathways that play important roles both in melanocyte specification and maintenance and in melanoma formation and progression. We are reviewing those genes and pathways to understand the connection between normal and cancerous development and to reveal therapeutic potential of targeting developmental pathways for melanoma therapy. äDevelopmental Pathways Activated in Melanocytes and Melanoma (epmc).pdf DeepDyve Pubget Overpricing