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10.1016/j.immuni.2014.08.017 http://scihub22266oqcxt.onion/10.1016/j.immuni.2014.08.017 C4220304!4220304!25367571     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2014 ; 41 (4): 543-54 Nephropedia Template TP {{tp|p=25367571|t=2014. The Identification of the Endogenous Ligands of Natural Killer T Cells Reveals the Presence of Mammalian ?-Linked Glycosylceramides |pdf=|usr=}}{{25367571}} gab.com Text The Identification of the Endogenous Ligands of Natural Killer T Cells Reveals the Presence of Mammalian -Linked Glycosylceramides JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=25367571 #FOAvip Glycosylceramides in mammalian species are thought to be present in the form of ?-anomers. This conclusion was reinforced by the identification of only one glucosylceramide and one galactosylcerhamide synthase, both ?-transferases, in mammalian genomes. Thus, the possibility that small amounts of ?-anomers could be produced by an alternative enzymatic pathway, by an unfaithful enzyme, or spontaneously in unusual cellular compartments has not been examined in detail. We approached the question by taking advantage of the exquisite specificity of T and B lymphocytes and combined it with the specificity of catabolic enzymes of the sphingolipid pathway. Here, we demonstrate that mammalian immune cells produce constitutively very small quantities of ?-glycosylceramides, which are the major endogenous ligands of natural killer T cells. Catabolic enzymes of the ceramide and glycolipid pathway tightly control the amount of these ?-glycosylceramides. The exploitation of this pathway to manipulate the immune response will create new therapeutic opportunities. Twit Text FOAVip The Identification of the Endogenous Ligands of Natural Killer T Cells Reveals the Presence of Mammalian -Linked Glycosylceramides ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=25367571 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25367571 #FOAvip English Wikipedia <ref>{{Cite pmid|25367571}}</ref> The Identification of the Endogenous Ligands of Natural Killer T Cells Reveals the Presence of Mammalian ?-Linked Glycosylceramides #MMPMID25367571 Kain L; Webb B; Anderson BL; Deng S; Holt M; Constanzo A; Zhao M; Self K; Teyton A; Everett C; Kronenberg M; Zajonc DM; Bendelac A; Savage PB; Teyton L Immunity 2014[Oct]; 41 (4): 543-54 PMID25367571show ga Glycosylceramides in mammalian species are thought to be present in the form of ?-anomers. This conclusion was reinforced by the identification of only one glucosylceramide and one galactosylcerhamide synthase, both ?-transferases, in mammalian genomes. Thus, the possibility that small amounts of ?-anomers could be produced by an alternative enzymatic pathway, by an unfaithful enzyme, or spontaneously in unusual cellular compartments has not been examined in detail. We approached the question by taking advantage of the exquisite specificity of T and B lymphocytes and combined it with the specificity of catabolic enzymes of the sphingolipid pathway. Here, we demonstrate that mammalian immune cells produce constitutively very small quantities of ?-glycosylceramides, which are the major endogenous ligands of natural killer T cells. Catabolic enzymes of the ceramide and glycolipid pathway tightly control the amount of these ?-glycosylceramides. The exploitation of this pathway to manipulate the immune response will create new therapeutic opportunities. äThe Identification of the Endogenous Ligands of Natural Killer T Cells(epmc).pdf DeepDyve Pubget Overpricing