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2014 ; 32
(32
): 3643-50
Nephropedia Template TP
gab.com Text
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English Wikipedia
Exercise and risk of major cardiovascular events in adult survivors of childhood
hodgkin lymphoma: a report from the childhood cancer survivor study
#MMPMID25311213
Jones LW
; Liu Q
; Armstrong GT
; Ness KK
; Yasui Y
; Devine K
; Tonorezos E
; Soares-Miranda L
; Sklar CA
; Douglas PS
; Robison LL
; Oeffinger KC
J Clin Oncol
2014[Nov]; 32
(32
): 3643-50
PMID25311213
show ga
PURPOSE: Survivors of Hodgkin lymphoma (HL) are at increased risk of
treatment-related cardiovascular (CV) events; whether exercise modifies this risk
is unknown. METHODS: Survivors of HL (n = 1,187; median age, 31.2 years)
completed a questionnaire evaluating vigorous-intensity exercise behavior. CV
events were collected in follow-up questionnaires and graded according to Common
Terminology Criteria for Adverse Events (version 4.03). The primary end point was
incidence of any major (grade 3 to 5) CV event. Poisson regression analyses were
used to estimate the association between exercise exposure (metabolic equivalent
[MET] hours/week(-1)) and risk of major CV events after adjustment for clinical
covariates and cancer treatment. RESULTS: Median follow-up was 11.9 years (range,
1.7 to 14.3 years). Cumulative incidence of any CV event was 12.2% at 10 years
for survivors reporting 0 MET hours/week(-1) compared with 5.2% for those
reporting ? 9 MET hours/week(-1). In multivariable analyses, the incidence of any
CV event decreased across increasing MET categories (Ptrend = .002). Compared
with survivors reporting 0 MET hours/week(-1), the adjusted rate ratio for any CV
event was 0.87 (95% CI, 0.56 to 1.34) for 3 to 6 MET hours/week(-1), 0.45 (95%
CI, 0.26 to 0.80) for 9 to 12 MET hours/week(-1), and 0.47 (95% CI, 0.23 to 0.95)
for 15 to 21 MET hours/week(-1). Adherence to national vigorous intensity
exercise guidelines (ie, ? 9 MET hours/week(-1)) was associated with a 51%
reduction in the risk of any CV event in comparison with not meeting the
guidelines (P = .002). CONCLUSION: Vigorous exercise was associated with a lower
risk of CV events in a dose-dependent manner independent of CV risk profile and
treatment in survivors of HL.