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2014 ; 29 Suppl 4
(Suppl 4
): iv142-53
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A stepwise approach for effective management of chronic pain in
autosomal-dominant polycystic kidney disease
#MMPMID25165181
Nephrol Dial Transplant
2014[Sep]; 29 Suppl 4
(Suppl 4
): iv142-53
PMID25165181
show ga
Chronic pain, defined as pain existing for >4-6 weeks, affects >60% of patients
with autosomal-dominant polycystic disease (ADPKD). It can have various causes,
indirectly or directly related to the increase in kidney and liver volume in
these patients. Chronic pain in ADPKD patients is often severe, impacting
physical activity and social relationships, and frequently difficult to manage.
This review provides an overview of pathophysiological mechanisms that can lead
to pain and discusses the sensory innervation of the kidneys and the upper
abdominal organs, including the liver. In addition, the results of a systematic
literature search of ADPKD-specific treatment options are presented. Based on
pathophysiological knowledge and evidence derived from the literature an
argumentative stepwise approach for effective management of chronic pain in ADPKD
is proposed.
|Chronic Pain/etiology/*prevention & control
[MESH]