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10.1073/pnas.1410700111 http://scihub22266oqcxt.onion/10.1073/pnas.1410700111 C4217470!4217470!25313073     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (43): 15502-7 Nephropedia Template TP {{tp|p=25313073|t=2014. Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells |pdf=|usr=}}{{25313073}} gab.com Text Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25313073 #FOAvip Interleukin-33 (IL-33) is an IL-1 family cytokine with important roles in type-2 immunity and human asthma. IL-33 is a key activator of the recently described group-2 innate lymphoid cells (ILC2s), which are involved in the initiation of allergic inflammation. Here, we investigated the mechanisms regulating IL-33 activity. We discovered that mast cells, critical effector cells in allergic disorders, secrete proteases, which cleave IL-33 and generate mature forms with increased biological activity. We demonstrate that these mature forms of IL-33 are 30-fold more potent than full-length IL-33 for activation of ILC2s. Our study suggests that inhibition of IL-33 cleavage by mast cell and other inflammatory proteases could be useful to limit IL-33?mediated responses in allergic asthma and other inflammatory diseases. Twit Text FOAVip Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25313073 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25313073 #FOAvip English Wikipedia <ref>{{Cite pmid|25313073}}</ref> Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells #MMPMID25313073 Lefrançais E; Duval A; Mirey E; Roga S; Espinosa E; Cayrol C; Girard JP Proc Natl Acad Sci U S A 2014[Oct]; 111 (43): 15502-7 PMID25313073show ga Interleukin-33 (IL-33) is an IL-1 family cytokine with important roles in type-2 immunity and human asthma. IL-33 is a key activator of the recently described group-2 innate lymphoid cells (ILC2s), which are involved in the initiation of allergic inflammation. Here, we investigated the mechanisms regulating IL-33 activity. We discovered that mast cells, critical effector cells in allergic disorders, secrete proteases, which cleave IL-33 and generate mature forms with increased biological activity. We demonstrate that these mature forms of IL-33 are 30-fold more potent than full-length IL-33 for activation of ILC2s. Our study suggests that inhibition of IL-33 cleavage by mast cell and other inflammatory proteases could be useful to limit IL-33?mediated responses in allergic asthma and other inflammatory diseases. äCentral domain of IL-33 is cleaved by mast cell proteases for potent a(epmc).pdf DeepDyve Pubget Overpricing