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10.1073/pnas.1408549111

http://scihub22266oqcxt.onion/10.1073/pnas.1408549111
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suck abstract from ncbi


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pmid25298532      Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (43): E4648-57
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  • Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by ?? T cells #MMPMID25298532
  • Roy S; Ly D; Li NS; Altman JD; Piccirilli JA; Moody DB; Adams EJ
  • Proc Natl Acad Sci U S A 2014[Oct]; 111 (43): E4648-57 PMID25298532show ga
  • Mycobacterium tuberculosis infects more than one-third of humans yet no effective vaccine exists. This study shows how a subset of ?? T cells targets M. tuberculosis lipid antigens that are presented by the MHC molecule CD1c. In contrast to many T cells that recognize CD1d, these ?? T cells express diverse T-cell receptors and have differing footprints on CD1c during lipid recognition. This study also shows that some CD1c-specific ?? T cells are exquisitely specific for the lipid presented, whereas others have a more promiscuous reactivity, demonstrating that the ?? T-cell response to CD1c lipid presentation is diverse and adaptable. These data may provide additional resources for development of MHC-independent vaccines against M. tuberculosis.
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