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10.1073/pnas.1324052111 http://scihub22266oqcxt.onion/10.1073/pnas.1324052111 C4217427!4217427!25313053     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (43): E4638-47 Nephropedia Template TP {{tp|p=25313053|t=2014. Spleen supports a pool of innate-like B cells in white adipose tissue that protects against obesity-associated insulin resistance |pdf=|usr=}}{{25313053}} gab.com Text Spleen supports a pool of innate-like B cells in white adipose tissue that protects against obesity-associated insulin resistance JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25313053 #FOAvip The rise in obesity-associated diseases has led to increased efforts to identify new therapeutic targets. Lipid accumulation in obesity triggers a low-grade inflammation that links obesity to its associated diseases, notably insulin resistance and type 2 diabetes. In this report, we have studied a group of innate-like B lymphocytes in visceral white adipose tissue (VAT) of mice that are (i) capable of producing the anti-inflammatory mediator IL-10; (ii) replenished from precursor cells in spleen during diet-induced obesity (DIO); and (iii) impaired in VAT of DIO mice, resulting in diminished protection against obesity-associated insulin resistance that can be ameliorated by supplementation of these cells. These findings identify spleen-supplied innate-like B cells in VAT as previously unidentified therapeutic targets for obesity-associated diseases. Twit Text FOAVip Spleen supports a pool of innate-like B cells in white adipose tissue that protects against obesity-associated insulin resistance ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25313053 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25313053 #FOAvip English Wikipedia <ref>{{Cite pmid|25313053}}</ref> Spleen supports a pool of innate-like B cells in white adipose tissue that protects against obesity-associated insulin resistance #MMPMID25313053 Wu L; Parekh VV; Hsiao J; Kitamura D; Van Kaer L Proc Natl Acad Sci U S A 2014[Oct]; 111 (43): E4638-47 PMID25313053show ga The rise in obesity-associated diseases has led to increased efforts to identify new therapeutic targets. Lipid accumulation in obesity triggers a low-grade inflammation that links obesity to its associated diseases, notably insulin resistance and type 2 diabetes. In this report, we have studied a group of innate-like B lymphocytes in visceral white adipose tissue (VAT) of mice that are (i) capable of producing the anti-inflammatory mediator IL-10; (ii) replenished from precursor cells in spleen during diet-induced obesity (DIO); and (iii) impaired in VAT of DIO mice, resulting in diminished protection against obesity-associated insulin resistance that can be ameliorated by supplementation of these cells. These findings identify spleen-supplied innate-like B cells in VAT as previously unidentified therapeutic targets for obesity-associated diseases. äSpleen supports a pool of innate-like B cells in white adipose tissue (epmc).pdf DeepDyve Pubget Overpricing