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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (43): 15480-5 Nephropedia Template TP
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Evolution of a morphological novelty occurred before genome compaction in a lineage of extreme parasites #MMPMID25313038
Haag KL; James TY; Pombert JF; Larsson R; Schaer TMM; Refardt D; Ebert D
Proc Natl Acad Sci U S A 2014[Oct]; 111 (43): 15480-5 PMID25313038show ga
Intracellular obligate parasitism results in extreme adaptations, whose evolutionary history is difficult to understand, because intermediate forms are hardly ever found. Microsporidia are highly derived intracellular parasites that are related to fungi. We describe the evolutionary history of a new microsporidian parasite found in the hindgut epithelium of the crustacean Daphnia and conclude that the new species has retained ancestral features that were lost in other microsporidia, whose hallmarks are the evolution of a unique infection apparatus, extreme genome reduction, and loss of mitochondrial respiration. The first evolutionary steps leading to the extreme metabolic and genomic simplification of microsporidia involved the adoption of a parasitic lifestyle, the development of a specialized infection apparatus, and the loss of diverse regulatory proteins.