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10.1073/pnas.1415762111 http://scihub22266oqcxt.onion/10.1073/pnas.1415762111 C4217397!4217397!25316791     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (43): E4658-67 Nephropedia Template TP {{tp|p=25316791|t=2014. Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis |pdf=|usr=}}{{25316791}} gab.com Text Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25316791 #FOAvip Tumor progression locus-2 (Tpl2) is a proinflammatory gene genetically associated with inflammatory bowel diseases. This study provides a mechanistic interpretation for this association showing a dominant Tpl2-mediated homeostatic mechanism protecting mice from epithelial injury-induced colitis. This function of Tpl2 is mediated specifically by subepithelial intestinal myofibroblasts, a cell type supporting crypt stem cells. Tpl2 in myofibroblasts is essential for the compensatory proliferative response of the epithelium by promoting arachidonic acid metabolism and cyclooxygenase-2 (Cox-2)/prostaglandin E2 activation. Notably, in Crohn?s Disease patients, Tpl2 is downregulated in myofibroblasts isolated from the inflamed ileum. These results challenge current concepts on a solely proinflammatory function of Tpl2 and highlight the dominant role of subepithelial myofibroblasts in sensing inflammation and tissue damage and promoting intestinal homeostasis through Tpl2-Cox-2-prostaglandin E2. Twit Text FOAVip Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25316791 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25316791 #FOAvip English Wikipedia <ref>{{Cite pmid|25316791}}</ref> Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis #MMPMID25316791 Roulis M; Nikolaou C; Kotsaki E; Kaffe E; Karagianni N; Koliaraki V; Salpea K; Ragoussis J; Aidinis V; Martini E; Becker C; Herschman HR; Vetrano S; Danese S; Kollias G Proc Natl Acad Sci U S A 2014[Oct]; 111 (43): E4658-67 PMID25316791show ga Tumor progression locus-2 (Tpl2) is a proinflammatory gene genetically associated with inflammatory bowel diseases. This study provides a mechanistic interpretation for this association showing a dominant Tpl2-mediated homeostatic mechanism protecting mice from epithelial injury-induced colitis. This function of Tpl2 is mediated specifically by subepithelial intestinal myofibroblasts, a cell type supporting crypt stem cells. Tpl2 in myofibroblasts is essential for the compensatory proliferative response of the epithelium by promoting arachidonic acid metabolism and cyclooxygenase-2 (Cox-2)/prostaglandin E2 activation. Notably, in Crohn?s Disease patients, Tpl2 is downregulated in myofibroblasts isolated from the inflamed ileum. These results challenge current concepts on a solely proinflammatory function of Tpl2 and highlight the dominant role of subepithelial myofibroblasts in sensing inflammation and tissue damage and promoting intestinal homeostasis through Tpl2-Cox-2-prostaglandin E2. äIntestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate(epmc).pdf DeepDyve Pubget Overpricing