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10.1098/rstb.2013.0549 http://scihub22266oqcxt.onion/10.1098/rstb.2013.0549 C4216470!4216470!25349456     free     free     free       Philos+Trans+R+Soc+Lond+B+Biol+Sci 2014 ; 369 (1657): ä Nephropedia Template TP {{tp|p=25349456|t=2014. The molecular underpinnings of totipotency |pdf=|usr=}}{{25349456}} gab.com Text The molecular underpinnings of totipotency JO: Philos Trans R Soc Lond B Biol Sci http://www.kidney.de/pget.php?&tw=1&pmid=25349456 #FOAvip Embryonic stem (ES) cells are characterized by their functional potency and capacity to self-renew in culture. Historically, ES cells have been defined as pluripotent, able to make the embryonic but not the extraembryonic lineages (such as the yolk sac and the placenta). The functional capacity of ES cells has been judged based on their ability to contribute to all somatic lineages when they are introduced into an embryo. However, a number of recent reports have suggested that under certain conditions, ES cells, and other reprogrammed cell lines, can also contribute to the extraembryonic lineages and, therefore, can be said to be totipotent. Here, we consider the molecular basis for this totipotent state, its transcriptional signature and the signalling pathways that define it. Twit Text FOAVip The molecular underpinnings of totipotency ????Philos Trans R Soc Lond B Biol Sci http://www.kidney.de/pget.php?&tw=1&pmid=25349456 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25349456 #FOAvip English Wikipedia <ref>{{Cite pmid|25349456}}</ref> The molecular underpinnings of totipotency #MMPMID25349456 Morgani SM; Brickman JM Philos Trans R Soc Lond B Biol Sci 2014[Dec]; 369 (1657): ä PMID25349456show ga Embryonic stem (ES) cells are characterized by their functional potency and capacity to self-renew in culture. Historically, ES cells have been defined as pluripotent, able to make the embryonic but not the extraembryonic lineages (such as the yolk sac and the placenta). The functional capacity of ES cells has been judged based on their ability to contribute to all somatic lineages when they are introduced into an embryo. However, a number of recent reports have suggested that under certain conditions, ES cells, and other reprogrammed cell lines, can also contribute to the extraembryonic lineages and, therefore, can be said to be totipotent. Here, we consider the molecular basis for this totipotent state, its transcriptional signature and the signalling pathways that define it. äThe molecular underpinnings of totipotency (epmc).pdf DeepDyve Pubget Overpricing