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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Philos+Trans+R+Soc+Lond+B+Biol+Sci 2014 ; 369 (1657): ä Nephropedia Template TP
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Gutsy moves in mice: cellular and molecular dynamics of endoderm morphogenesis #MMPMID25349455
Viotti M; Foley AC; Hadjantonakis AK
Philos Trans R Soc Lond B Biol Sci 2014[Dec]; 369 (1657): ä PMID25349455show ga
Despite the importance of the gut and its accessory organs, our understanding of early endoderm development is still incomplete. Traditionally, endoderm has been difficult to study because of its small size and relative fragility. However, recent advances in live cell imaging technologies have dramatically expanded our understanding of this tissue, adding a new appreciation for the complex molecular and morphogenetic processes that mediate gut formation. Several spatially and molecularly distinct subpopulations have been shown to exist within the endoderm before the onset of gastrulation. Here, we review findings that have uncovered complex cell movements within the endodermal layer, before and during gastrulation, leading to the conclusion that cells from primitive endoderm contribute descendants directly to gut.