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10.1098/rstb.2013.0536

http://scihub22266oqcxt.onion/10.1098/rstb.2013.0536
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C4216459!4216459!25349445
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suck abstract from ncbi


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pmid25349445      Philos+Trans+R+Soc+Lond+B+Biol+Sci 2014 ; 369 (1657): ä
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  • Origin of cellular asymmetries in the pre-implantation mouse embryo: a hypothesis #MMPMID25349445
  • Takaoka K; Hamada H
  • Philos Trans R Soc Lond B Biol Sci 2014[Dec]; 369 (1657): ä PMID25349445show ga
  • The first cell fate decision during mouse development concerns whether a blastomere will contribute to the inner cell mass (ICM; which gives rise to the embryo proper) or to trophectoderm (TE; which gives rise to the placenta). The position of a cell within an 8- to 16-cell-stage embryo correlates with its future fate, with outer cells contributing to TE and inner cells to the ICM. It remains unknown, however, whether an earlier pre-pattern exists. Here, we propose a hypothesis that could account for generation of such a pre-pattern and which is based on epigenetic asymmetry (such as in histone or DNA methylation) between maternal and paternal genomes in the zygote.
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