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10.1038/ncomms6202 http://scihub22266oqcxt.onion/10.1038/ncomms6202 C4215647!4215647!25351346     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25351346&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2014 ; 5 (ä): 5202 Nephropedia Template TP {{tp|p=25351346|t=2014. Hypoxia Mediated Downregulation of miRNA Biogenesis Promotes Tumor Progression |pdf=|usr=}}{{25351346}} gab.com Text Hypoxia Mediated Downregulation of miRNA Biogenesis Promotes Tumor Progression JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25351346 #FOAvip Cancer-related deregulation of miRNA biogenesis has been suggested, but the underlying mechanisms remain elusive. Here, we report a previously unrecognized effect of hypoxia in the downregulation of Drosha and Dicer in cancer cells that leads to dysregulation of miRNA biogenesis and increased tumor progression. We show that hypoxia mediated downregulation of Drosha is dependent on ETS1/ELK1 transcription factors. Moreover, mature miRNA array and deep sequencing studies reveal altered miRNA maturation in cells under hypoxic conditions. At a functional level, this phenomenon results in increased cancer progression in vitro and in vivo, and data from patient samples are suggestive of miRNA biogenesis downregulation in hypoxic tumors. Rescue of Drosha by siRNAs targeting ETS1/ELK1 in vivo results in significant tumor regression. These findings provide a new link in the mechanistic understanding of global miRNA downregulation in the tumor microenvironment. Twit Text FOAVip Hypoxia Mediated Downregulation of miRNA Biogenesis Promotes Tumor Progression ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25351346 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25351346 #FOAvip English Wikipedia <ref>{{Cite pmid|25351346}}</ref> Hypoxia Mediated Downregulation of miRNA Biogenesis Promotes Tumor Progression #MMPMID25351346 Rupaimoole R; Wu SY; Pradeep S; Ivan C; Pecot CV; Gharpure KM; Nagaraja AS; Armaiz-Pena GN; McGuire M; Zand B; Dalton HJ; Filant J; Miller JB; Lu C; Sadaoui NC; Mangala LS; Taylor M; van den Beucken T; Koch E; Rodriguez-Aguayo C; Huang L; Bar-Eli M; Wouters BG; Radovich M; Ivan M; Calin GA; Zhang W; Lopez-Berestein G; Sood AK Nat Commun 2014[]; 5 (ä): 5202 PMID25351346show ga Cancer-related deregulation of miRNA biogenesis has been suggested, but the underlying mechanisms remain elusive. Here, we report a previously unrecognized effect of hypoxia in the downregulation of Drosha and Dicer in cancer cells that leads to dysregulation of miRNA biogenesis and increased tumor progression. We show that hypoxia mediated downregulation of Drosha is dependent on ETS1/ELK1 transcription factors. Moreover, mature miRNA array and deep sequencing studies reveal altered miRNA maturation in cells under hypoxic conditions. At a functional level, this phenomenon results in increased cancer progression in vitro and in vivo, and data from patient samples are suggestive of miRNA biogenesis downregulation in hypoxic tumors. Rescue of Drosha by siRNAs targeting ETS1/ELK1 in vivo results in significant tumor regression. These findings provide a new link in the mechanistic understanding of global miRNA downregulation in the tumor microenvironment. äHypoxia Mediated Downregulation of miRNA Biogenesis Promotes Tumor Pro(epmc).pdf DeepDyve Pubget Overpricing