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10.7554/eLife.03711 http://scihub22266oqcxt.onion/10.7554/eLife.03711 C4215537!4215537 !25317947     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25317947 &cmd=llinks): Failed to open stream: HTTP request failed! 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Female resistance to pneumonia identifies lung macrophage nitric oxide synthase-3 as a therapeutic target |pdf=|usr=}}{{25317947 }} gab.com Text Female resistance to pneumonia identifies lung macrophage nitric oxide synthase-3 as a therapeutic target JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=25317947 #FOAvip To identify new approaches to enhance innate immunity to bacterial pneumonia, we investigated the natural experiment of gender differences in resistance to infections. Female and estrogen-treated male mice show greater resistance to pneumococcal pneumonia, seen as greater bacterial clearance, diminished lung inflammation, and better survival. In vitro, lung macrophages from female mice and humans show better killing of ingested bacteria. Inhibitors and genetically altered mice identify a critical role for estrogen-mediated activation of lung macrophage nitric oxide synthase-3 (NOS3). Epidemiologic data show decreased hospitalization for pneumonia in women receiving estrogen or statins (known to activate NOS3). Pharmacologic targeting of NOS3 with statins or another small-molecule compound (AVE3085) enhanced macrophage bacterial killing, improved bacterial clearance, and increased host survival in both primary and secondary (post-influenza) pneumonia. The data identify a novel mechanism for host defense via NOS3 and suggest a potential therapeutic strategy to reduce secondary bacterial pneumonia after influenza. Twit Text FOAVip Female resistance to pneumonia identifies lung macrophage nitric oxide synthase-3 as a therapeutic target ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=25317947 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25317947 #FOAvip English Wikipedia <ref>{{Cite pmid|25317947 }}</ref> Female resistance to pneumonia identifies lung macrophage nitric oxide synthase-3 as a therapeutic target #MMPMID25317947 Yang Z ; Huang YC ; Koziel H ; de Crom R ; Ruetten H ; Wohlfart P ; Thomsen RW ; Kahlert JA ; Sørensen HT ; Jozefowski S ; Colby A ; Kobzik L Elife 2014[Oct]; 3 (ä): ä PMID25317947 show ga To identify new approaches to enhance innate immunity to bacterial pneumonia, we investigated the natural experiment of gender differences in resistance to infections. Female and estrogen-treated male mice show greater resistance to pneumococcal pneumonia, seen as greater bacterial clearance, diminished lung inflammation, and better survival. In vitro, lung macrophages from female mice and humans show better killing of ingested bacteria. Inhibitors and genetically altered mice identify a critical role for estrogen-mediated activation of lung macrophage nitric oxide synthase-3 (NOS3). Epidemiologic data show decreased hospitalization for pneumonia in women receiving estrogen or statins (known to activate NOS3). Pharmacologic targeting of NOS3 with statins or another small-molecule compound (AVE3085) enhanced macrophage bacterial killing, improved bacterial clearance, and increased host survival in both primary and secondary (post-influenza) pneumonia. The data identify a novel mechanism for host defense via NOS3 and suggest a potential therapeutic strategy to reduce secondary bacterial pneumonia after influenza. |*Immunity, Innate/drug effects [MESH] |*Molecular Targeted Therapy [MESH] |Adolescent [MESH] |Adult [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Animals [MESH] |Benzodioxoles/pharmacology/therapeutic use [MESH] |Case-Control Studies [MESH] |Estrogens/pharmacology [MESH] |Female [MESH] |Hospitalization [MESH] |Humans [MESH] |Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology/therapeutic use [MESH] |Indans/pharmacology/therapeutic use [MESH] |Macrophage Activation/drug effects [MESH] |Macrophages, Alveolar/drug effects/*enzymology [MESH] |Male [MESH] |Mice, Inbred C57BL [MESH] |Microbial Viability/drug effects [MESH] |Middle Aged [MESH] |Nitric Oxide Synthase Type III/*metabolism [MESH] |Odds Ratio [MESH] |Phagocytosis/drug effects [MESH] |Pneumonia, Pneumococcal/*enzymology/*immunology/pathology/therapy [MESH]Female resistance to pneumonia identifies lung macrophage nitric oxide(epmc).pdf DeepDyve Pubget Overpricing