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10.1182/blood-2014-04-526301 http://scihub22266oqcxt.onion/10.1182/blood-2014-04-526301 C4215310!4215310!25237201     free     free     free       Blood 2014 ; 124 (18): 2784-92 Nephropedia Template TP {{tp|p=25237201|t=2014. Marrow failure: a window into ribosome biology |pdf=|usr=}}{{25237201}} gab.com Text Marrow failure: a window into ribosome biology JO: Blood http://www.kidney.de/pget.php?&tw=1&pmid=25237201 #FOAvip Diamond-Blackfan anemia, Shwachman-Diamond syndrome, and dyskeratosis congenita are inherited syndromes characterized by marrow failure, congenital anomalies, and cancer predisposition. Genetic and molecular studies have uncovered distinct abnormalities in ribosome biogenesis underlying each of these 3 disorders. How defects in ribosomes, the essential organelles required for protein biosynthesis in all cells, cause tissue-specific abnormalities in human disease remains a question of fundamental scientific and medical importance. Here we review the overlapping and distinct clinical features of these 3 syndromes and discuss current knowledge regarding the ribosomal pathways disrupted in each of these disorders. We also explore the increasing complexity of ribosome biology and how this informs our understanding of developmental biology and human disease. Twit Text FOAVip Marrow failure: a window into ribosome biology ????Blood http://www.kidney.de/pget.php?&tw=1&pmid=25237201 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25237201 #FOAvip English Wikipedia <ref>{{Cite pmid|25237201}}</ref> Marrow failure: a window into ribosome biology #MMPMID25237201 Ruggero D; Shimamura A Blood 2014[Oct]; 124 (18): 2784-92 PMID25237201show ga Diamond-Blackfan anemia, Shwachman-Diamond syndrome, and dyskeratosis congenita are inherited syndromes characterized by marrow failure, congenital anomalies, and cancer predisposition. Genetic and molecular studies have uncovered distinct abnormalities in ribosome biogenesis underlying each of these 3 disorders. How defects in ribosomes, the essential organelles required for protein biosynthesis in all cells, cause tissue-specific abnormalities in human disease remains a question of fundamental scientific and medical importance. Here we review the overlapping and distinct clinical features of these 3 syndromes and discuss current knowledge regarding the ribosomal pathways disrupted in each of these disorders. We also explore the increasing complexity of ribosome biology and how this informs our understanding of developmental biology and human disease. äMarrow failure: a window into ribosome biology (epmc).pdf DeepDyve Pubget Overpricing