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10.1074/jbc.M114.588384

http://scihub22266oqcxt.onion/10.1074/jbc.M114.588384
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C4215212!4215212!25228692
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suck abstract from ncbi


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pmid25228692      J+Biol+Chem 2014 ; 289 (44): 30279-88
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  • Sustained Down-regulation of ?-Dystroglycan and Associated Dysfunctions of Astrocytic Endfeet in Epileptic Cerebral Cortex* #MMPMID25228692
  • Gondo A; Shinotsuka T; Morita A; Abe Y; Yasui M; Nuriya M
  • J Biol Chem 2014[Oct]; 289 (44): 30279-88 PMID25228692show ga
  • Background: The molecular and cellular changes of astrocytes in epileptic cerebral cortex are poorly understood.Results: In the epileptic cortex, ?-dystroglycan is down-regulated in a sustained manner with a concomitant impairment in the integrity of the astrocyte endfeet.Conclusion: Astrocyte endfeet undergo long lasting changes in the epileptic cortex.Significance: The pathological changes of astrocyte endfeet could be a new therapeutic target for epilepsy.
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