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10.1074/jbc.R114.567081 http://scihub22266oqcxt.onion/10.1074/jbc.R114.567081 C4215203!4215203 !25210030     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25210030 &cmd=llinks): Failed to open stream: HTTP request failed! 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Massive thermal acceleration of the emergence of primordial chemistry, the incidence of spontaneous mutation, and the evolution of enzymes |pdf=|usr=}}{{25210030 }} gab.com Text Massive thermal acceleration of the emergence of primordial chemistry, the incidence of spontaneous mutation, and the evolution of enzymes JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25210030 #FOAvip Kelvin considered it unlikely that sufficient time had elapsed on the earth for life to have reached its present level of complexity. In the warm surroundings in which life first appeared, however, elevated temperatures would have reduced the kinetic barriers to reaction. Recent experiments disclose the profound extent to which very slow reactions are accelerated by elevated temperatures, collapsing the time that would have been required for early events in primordial chemistry before the advent of enzymes. If a primitive enzyme, like model catalysts and most modern enzymes, accelerated a reaction by lowering its enthalpy of activation, then the rate enhancement that it produced would have increased automatically as the environment cooled, quite apart from any improvements in catalytic activity that arose from mutation and natural selection. The chemical events responsible for spontaneous mutation are also highly sensitive to temperature, furnishing an independent mechanism for accelerating evolution. Twit Text FOAVip Massive thermal acceleration of the emergence of primordial chemistry, the incidence of spontaneous mutation, and the evolution of enzymes ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25210030 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25210030 #FOAvip English Wikipedia <ref>{{Cite pmid|25210030 }}</ref> Massive thermal acceleration of the emergence of primordial chemistry, the incidence of spontaneous mutation, and the evolution of enzymes #MMPMID25210030 Wolfenden R J Biol Chem 2014[Oct]; 289 (44 ): 30198-30204 PMID25210030 show ga Kelvin considered it unlikely that sufficient time had elapsed on the earth for life to have reached its present level of complexity. In the warm surroundings in which life first appeared, however, elevated temperatures would have reduced the kinetic barriers to reaction. Recent experiments disclose the profound extent to which very slow reactions are accelerated by elevated temperatures, collapsing the time that would have been required for early events in primordial chemistry before the advent of enzymes. If a primitive enzyme, like model catalysts and most modern enzymes, accelerated a reaction by lowering its enthalpy of activation, then the rate enhancement that it produced would have increased automatically as the environment cooled, quite apart from any improvements in catalytic activity that arose from mutation and natural selection. The chemical events responsible for spontaneous mutation are also highly sensitive to temperature, furnishing an independent mechanism for accelerating evolution. |*Evolution, Molecular [MESH] |Biocatalysis [MESH] |Enzyme Stability [MESH] |Enzymes/chemistry/*genetics [MESH] |Half-Life [MESH] |Humans [MESH] |Kinetics [MESH] |Mutation [MESH]Massive thermal acceleration of the emergence of primordial chemistry,(epmc).pdf DeepDyve Pubget Overpricing