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10.1038/nature13839 http://scihub22266oqcxt.onion/10.1038/nature13839 C4214889!4214889!25317562     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nature 2014 ; 514 (7524): 585-90 Nephropedia Template TP {{tp|p=25317562|t=2014. Mesenchymal-endothelial-transition contributes to cardiac neovascularization |pdf=|usr=}}{{25317562}} gab.com Text Mesenchymal-endothelial-transition contributes to cardiac neovascularization JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=25317562 #FOAvip Endothelial cells contribute to a subset of cardiac fibroblasts by undergoing endothelial-to-mesenchymal-transition, but whether cardiac fibroblasts can adopt an endothelial cell fate and directly contribute to neovascularization after cardiac injury is not known. Here, using genetic fate map techniques, we demonstrate that cardiac fibroblasts rapidly adopt an endothelial cell like phenotype after acute ischemic cardiac injury. Fibroblast derived endothelial cells exhibit anatomical and functional characteristics of native endothelial cells. We show that the transcription factor p53 regulates such a switch in cardiac fibroblast fate. Loss of p53 in cardiac fibroblasts severely decreases the formation of fibroblast derived endothelial cells, reduces post infarct vascular density and worsens cardiac function. Conversely, stimulation of the p53 pathway in cardiac fibroblasts augments mesenchymal to endothelial transition, enhances vascularity and improves cardiac function. These observations demonstrate that mesenchymal-to-endothelial-transition contributes to neovascularization of the injured heart and represents a potential therapeutic target for enhancing cardiac repair. Twit Text FOAVip Mesenchymal-endothelial-transition contributes to cardiac neovascularization ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=25317562 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25317562 #FOAvip English Wikipedia <ref>{{Cite pmid|25317562}}</ref> Mesenchymal-endothelial-transition contributes to cardiac neovascularization #MMPMID25317562 Ubil E; Duan J; Pillai IC; Rosa-Garrido M; Wu Y; Bargiacchi F; Lu Y; Stanbouly S; Huang J; Rojas M; Vondriska TM; Stefani E; Deb A Nature 2014[Oct]; 514 (7524): 585-90 PMID25317562show ga Endothelial cells contribute to a subset of cardiac fibroblasts by undergoing endothelial-to-mesenchymal-transition, but whether cardiac fibroblasts can adopt an endothelial cell fate and directly contribute to neovascularization after cardiac injury is not known. Here, using genetic fate map techniques, we demonstrate that cardiac fibroblasts rapidly adopt an endothelial cell like phenotype after acute ischemic cardiac injury. Fibroblast derived endothelial cells exhibit anatomical and functional characteristics of native endothelial cells. We show that the transcription factor p53 regulates such a switch in cardiac fibroblast fate. Loss of p53 in cardiac fibroblasts severely decreases the formation of fibroblast derived endothelial cells, reduces post infarct vascular density and worsens cardiac function. Conversely, stimulation of the p53 pathway in cardiac fibroblasts augments mesenchymal to endothelial transition, enhances vascularity and improves cardiac function. These observations demonstrate that mesenchymal-to-endothelial-transition contributes to neovascularization of the injured heart and represents a potential therapeutic target for enhancing cardiac repair. äMesenchymal-endothelial-transition contributes to cardiac neovasculari(epmc).pdf DeepDyve Pubget Overpricing