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10.1113/jphysiol.2013.270389

http://scihub22266oqcxt.onion/10.1113/jphysiol.2013.270389
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C4214654!4214654!24665099
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suck abstract from ncbi


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pmid24665099      J+Physiol 2014 ; 592 (Pt 14): 2981-8
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  • It s a gut feeling: How the gut microbiota affects the state of mind #MMPMID24665099
  • Farmer AD; Randall HA; Aziz Q
  • J Physiol 2014[Jul]; 592 (Pt 14): 2981-8 PMID24665099show ga
  • Common human experience shows that stress and anxiety may modulate gut function. Such observations have been combined with an increasing evidence base that has culminated in the concept of the brain?gut axis. Nevertheless, it has not been until recently that the gut and its attendant components have been considered to influence higher cerebral function and behaviour per se. Moreover, the proposal that the gut and the bacteria contained therein (collectively referred to as the microbiota) can modulate mood and behaviours, has an increasing body of supporting evidence, albeit largely derived from animal studies. The gut microbiota is a dynamic and diverse ecosystem and forms a symbiotic relationship with the host. Herein we describe the components of the gut microbiota and mechanisms by which it can influence neural development, complex behaviours and nociception. Furthermore, we propose the novel concept of a ?state of gut? rather than a state of mind, particularly in relation to functional bowel disorders. Finally, we address the exciting possibility that the gut microbiota may offer a novel area of therapeutic intervention across a diverse array of both affective and gastrointestinal disorders.
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