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10.1681/ASN.2013101052 http://scihub22266oqcxt.onion/10.1681/ASN.2013101052 C4214528!4214528 !24744438     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24744438 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Am+Soc+Nephrol 2014 ; 25 (11 ): 2471-82 Nephropedia Template TP {{tp|p=24744438 |t=2014. Cytomegalovirus-responsive ?? T cells: novel effector cells in antibody-mediated kidney allograft microcirculation lesions |pdf=|usr=}}{{24744438 }} gab.com Text Cytomegalovirus-responsive T cells: novel effector cells in antibody-mediated kidney allograft microcirculation lesions JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=24744438 #FOAvip Human cytomegalovirus infection in transplant recipients has been associated with adverse renal allograft outcome and with a large ?? T-cell response, but whether both mechanisms are connected is unknown. We previously showed that most expanded circulating cytomegalovirus-responsive ?? T cells express the Fc?-receptor CD16, suggesting that ?? T cells may participate in allograft lesions mediated by donor-specific antibodies through antibody-dependent cellular cytotoxicity. Here, we show that cytomegalovirus-specific CD16(pos) ?? T cells can perform antibody-dependent cellular cytotoxicity against stromal cells coated with donor-specific antibodies in vitro. In vivo, graft-infiltrating ?? T cells localized in close contact with endothelial cells only in patients who experienced cytomegalovirus infection and were more frequent within peritubular capillaries and glomeruli from antibody-mediated acute rejections than within those from T cell-mediated acute rejections. Finally, a persistently increased percentage of circulating cytomegalovirus-induced ?? T cells correlated inversely with the 1-year eGFR only in kidney recipients with donor-specific antibodies. Collectively, these data support the conclusion that cytomegalovirus-induced ?? T cells are involved in, and may serve as a clinical biomarker of, antibody-mediated lesions of kidney transplants. Moreover, these findings offer a new physiopathologic link between cytomegalovirus infection and allograft dysfunction in recipients with donor-specific antibodies. Twit Text FOAVip Cytomegalovirus-responsive T cells: novel effector cells in antibody-mediated kidney allograft microcirculation lesions ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=24744438 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24744438 #FOAvip English Wikipedia <ref>{{Cite pmid|24744438 }}</ref> Cytomegalovirus-responsive ?? T cells: novel effector cells in antibody-mediated kidney allograft microcirculation lesions #MMPMID24744438 Bachelet T ; Couzi L ; Pitard V ; Sicard X ; Rigothier C ; Lepreux S ; Moreau JF ; Taupin JL ; Merville P ; Déchanet-Merville J J Am Soc Nephrol 2014[Nov]; 25 (11 ): 2471-82 PMID24744438 show ga Human cytomegalovirus infection in transplant recipients has been associated with adverse renal allograft outcome and with a large ?? T-cell response, but whether both mechanisms are connected is unknown. We previously showed that most expanded circulating cytomegalovirus-responsive ?? T cells express the Fc?-receptor CD16, suggesting that ?? T cells may participate in allograft lesions mediated by donor-specific antibodies through antibody-dependent cellular cytotoxicity. Here, we show that cytomegalovirus-specific CD16(pos) ?? T cells can perform antibody-dependent cellular cytotoxicity against stromal cells coated with donor-specific antibodies in vitro. In vivo, graft-infiltrating ?? T cells localized in close contact with endothelial cells only in patients who experienced cytomegalovirus infection and were more frequent within peritubular capillaries and glomeruli from antibody-mediated acute rejections than within those from T cell-mediated acute rejections. Finally, a persistently increased percentage of circulating cytomegalovirus-induced ?? T cells correlated inversely with the 1-year eGFR only in kidney recipients with donor-specific antibodies. Collectively, these data support the conclusion that cytomegalovirus-induced ?? T cells are involved in, and may serve as a clinical biomarker of, antibody-mediated lesions of kidney transplants. Moreover, these findings offer a new physiopathologic link between cytomegalovirus infection and allograft dysfunction in recipients with donor-specific antibodies. |Adolescent [MESH] |Adult [MESH] |Aged [MESH] |Cell Line, Transformed [MESH] |Cytomegalovirus Infections/*immunology/pathology [MESH] |Endothelium, Vascular/cytology/immunology [MESH] |Female [MESH] |Fibroblasts/cytology/immunology [MESH] |GPI-Linked Proteins/immunology [MESH] |Graft Rejection/*immunology [MESH] |Histocompatibility Testing [MESH] |Human Umbilical Vein Endothelial Cells [MESH] |Humans [MESH] |Isoantibodies/*immunology [MESH] |Kidney Transplantation/*adverse effects [MESH] |Killer Cells, Natural/immunology [MESH] |Male [MESH] |Microcirculation/immunology [MESH] |Middle Aged [MESH] |Perforin [MESH] |Pore Forming Cytotoxic Proteins/immunology [MESH] |Receptors, Antigen, T-Cell, gamma-delta/*immunology [MESH] |Receptors, IgG/immunology [MESH] |Transplantation, Homologous [MESH]Cytomegalovirus-responsive ?? T cells: novel effector cells in antibod(epmc).pdf DeepDyve Pubget Overpricing