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10.1158/0008-5472.CAN-14-1171 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-14-1171 C4214267!4214267!25261235     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Res 2014 ; 74 (20): 5683-9 Nephropedia Template TP {{tp|p=25261235|t=2014. DEAR1, a Novel Tumor Suppressor that Regulates Cell Polarity and Epithelial Plasticity |pdf=|usr=}}{{25261235}} gab.com Text DEAR1, a Novel Tumor Suppressor that Regulates Cell Polarity and Epithelial Plasticity JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25261235 #FOAvip Elucidation of the regulatory controls on epithelial plasticity is pivotal not only to better understand the nature of metastasis, but also for the design of targeted therapies to prevent the earliest steps in migration and invasion from the primary tumor. This review will highlight the role of the novel TRIM protein DEAR1 (annotated as TRIM62) in the regulation of apical-basal polarity and acinar morphogenesis as well as its function as a chromosome 1p35 tumor suppressor and negative regulator of TGF?-driven epithelial-mesenchymal transition (EMT). DEAR1 binds to and promotes the ubiquitination of SMAD3, the major effector of TGF?-mediated EMT, as well as downregulates SMAD3 targets SNAIL1/2, master transcriptional regulators of EMT. Cumulative results suggest a novel paradigm for DEAR1 in the regulation of the breast tumor microenvironment, polarity and EMT. Because DEAR1 undergoes loss of function mutations, homozygous deletion as well as copy number losses in multiple epithelial cancers including breast cancer, DEAR1 has clinical utility as a predictive and prognostic biomarker as well as for stratifying breast cancers and potentially other epithelial tumor types for targeted therapies aimed at the pathways regulated by DEAR1. Twit Text FOAVip DEAR1, a Novel Tumor Suppressor that Regulates Cell Polarity and Epithelial Plasticity ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25261235 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25261235 #FOAvip English Wikipedia <ref>{{Cite pmid|25261235}}</ref> DEAR1, a Novel Tumor Suppressor that Regulates Cell Polarity and Epithelial Plasticity #MMPMID25261235 Chen N; Balasenthil S; Reuther J; Killary AM Cancer Res 2014[Oct]; 74 (20): 5683-9 PMID25261235show ga Elucidation of the regulatory controls on epithelial plasticity is pivotal not only to better understand the nature of metastasis, but also for the design of targeted therapies to prevent the earliest steps in migration and invasion from the primary tumor. This review will highlight the role of the novel TRIM protein DEAR1 (annotated as TRIM62) in the regulation of apical-basal polarity and acinar morphogenesis as well as its function as a chromosome 1p35 tumor suppressor and negative regulator of TGF?-driven epithelial-mesenchymal transition (EMT). DEAR1 binds to and promotes the ubiquitination of SMAD3, the major effector of TGF?-mediated EMT, as well as downregulates SMAD3 targets SNAIL1/2, master transcriptional regulators of EMT. Cumulative results suggest a novel paradigm for DEAR1 in the regulation of the breast tumor microenvironment, polarity and EMT. Because DEAR1 undergoes loss of function mutations, homozygous deletion as well as copy number losses in multiple epithelial cancers including breast cancer, DEAR1 has clinical utility as a predictive and prognostic biomarker as well as for stratifying breast cancers and potentially other epithelial tumor types for targeted therapies aimed at the pathways regulated by DEAR1. äDEAR1, a Novel Tumor Suppressor that Regulates Cell Polarity and Epith(epmc).pdf DeepDyve Pubget Overpricing