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10.1016/j.bpj.2014.08.029 http://scihub22266oqcxt.onion/10.1016/j.bpj.2014.08.029 C4213674!4213674 !25418164     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25418164 &cmd=llinks): Failed to open stream: HTTP request failed! 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Remodeling of fibrous extracellular matrices by contractile cells: predictions from discrete fiber network simulations |pdf=|usr=}}{{25418164 }} gab.com Text Remodeling of fibrous extracellular matrices by contractile cells: predictions from discrete fiber network simulations JO: Biophys J http://www.kidney.de/pget.php?&tw=1&pmid=25418164 #FOAvip Contractile forces exerted on the surrounding extracellular matrix (ECM) lead to the alignment and stretching of constituent fibers within the vicinity of cells. As a consequence, the matrix reorganizes to form thick bundles of aligned fibers that enable force transmission over distances larger than the size of the cells. Contractile force-mediated remodeling of ECM fibers has bearing on a number of physiologic and pathophysiologic phenomena. In this work, we present a computational model to capture cell-mediated remodeling within fibrous matrices using finite element-based discrete fiber network simulations. The model is shown to accurately capture collagen alignment, heterogeneous deformations, and long-range force transmission observed experimentally. The zone of mechanical influence surrounding a single contractile cell and the interaction between two cells are predicted from the strain-induced alignment of fibers. Through parametric studies, the effect of cell contractility and cell shape anisotropy on matrix remodeling and force transmission are quantified and summarized in a phase diagram. For highly contractile and elongated cells, we find a sensing distance that is ten times the cell size, in agreement with experimental observations. Twit Text FOAVip Remodeling of fibrous extracellular matrices by contractile cells: predictions from discrete fiber network simulations ????Biophys J http://www.kidney.de/pget.php?&tw=1&pmid=25418164 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25418164 #FOAvip English Wikipedia <ref>{{Cite pmid|25418164 }}</ref> Remodeling of fibrous extracellular matrices by contractile cells: predictions from discrete fiber network simulations #MMPMID25418164 Abhilash AS ; Baker BM ; Trappmann B ; Chen CS ; Shenoy VB Biophys J 2014[Oct]; 107 (8 ): 1829-1840 PMID25418164 show ga Contractile forces exerted on the surrounding extracellular matrix (ECM) lead to the alignment and stretching of constituent fibers within the vicinity of cells. As a consequence, the matrix reorganizes to form thick bundles of aligned fibers that enable force transmission over distances larger than the size of the cells. Contractile force-mediated remodeling of ECM fibers has bearing on a number of physiologic and pathophysiologic phenomena. In this work, we present a computational model to capture cell-mediated remodeling within fibrous matrices using finite element-based discrete fiber network simulations. The model is shown to accurately capture collagen alignment, heterogeneous deformations, and long-range force transmission observed experimentally. The zone of mechanical influence surrounding a single contractile cell and the interaction between two cells are predicted from the strain-induced alignment of fibers. Through parametric studies, the effect of cell contractility and cell shape anisotropy on matrix remodeling and force transmission are quantified and summarized in a phase diagram. For highly contractile and elongated cells, we find a sensing distance that is ten times the cell size, in agreement with experimental observations. |*Molecular Dynamics Simulation [MESH] |Collagen/*chemistry [MESH] |Elasticity [MESH]Remodeling of fibrous extracellular matrices by contractile cells: pre(epmc).pdf DeepDyve Pubget Overpricing