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10.1098/rspb.2014.1662 http://scihub22266oqcxt.onion/10.1098/rspb.2014.1662 C4213641!4213641!25339723     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Biol+Sci 2014 ; 281 (1796): ä Nephropedia Template TP {{tp|p=25339723|t=2014. Sexual selection and the evolutionary dynamics of the major histocompatibility complex |pdf=|usr=}}{{25339723}} gab.com Text Sexual selection and the evolutionary dynamics of the major histocompatibility complex JO: Proc Biol Sci http://www.kidney.de/pget.php?&tw=1&pmid=25339723 #FOAvip The genes of the major histocompatibility complex (MHC) are a key component of the adaptive immune system and among the most variable loci in the vertebrate genome. Pathogen-mediated natural selection and MHC-based disassortative mating are both thought to structure MHC polymorphism, but their effects have proven difficult to discriminate in natural systems. Using the first model of MHC dynamics incorporating both survival and reproduction, we demonstrate that natural and sexual selection produce distinctive signatures of MHC allelic diversity with critical implications for understanding host?pathogen dynamics. While natural selection produces the Red Queen dynamics characteristic of host?parasite interactions, disassortative mating stabilizes allele frequencies, damping major fluctuations in dominant alleles and protecting functional variants against drift. This subtle difference generates a complex interaction between MHC allelic diversity and population size. In small populations, the stabilizing effects of sexual selection moderate the effects of drift, whereas pathogen-mediated selection accelerates the loss of functionally important genetic diversity. Natural selection enhances MHC allelic variation in larger populations, with the highest levels of diversity generated by the combined action of pathogen-mediated selection and disassortative mating. MHC-based sexual selection may help to explain how functionally important genetic variation can be maintained in populations of conservation concern. Twit Text FOAVip Sexual selection and the evolutionary dynamics of the major histocompatibility complex ????Proc Biol Sci http://www.kidney.de/pget.php?&tw=1&pmid=25339723 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25339723 #FOAvip English Wikipedia <ref>{{Cite pmid|25339723}}</ref> Sexual selection and the evolutionary dynamics of the major histocompatibility complex #MMPMID25339723 Jan Ejsmond M; Radwan J; Wilson AB Proc Biol Sci 2014[Dec]; 281 (1796): ä PMID25339723show ga The genes of the major histocompatibility complex (MHC) are a key component of the adaptive immune system and among the most variable loci in the vertebrate genome. Pathogen-mediated natural selection and MHC-based disassortative mating are both thought to structure MHC polymorphism, but their effects have proven difficult to discriminate in natural systems. Using the first model of MHC dynamics incorporating both survival and reproduction, we demonstrate that natural and sexual selection produce distinctive signatures of MHC allelic diversity with critical implications for understanding host?pathogen dynamics. While natural selection produces the Red Queen dynamics characteristic of host?parasite interactions, disassortative mating stabilizes allele frequencies, damping major fluctuations in dominant alleles and protecting functional variants against drift. This subtle difference generates a complex interaction between MHC allelic diversity and population size. In small populations, the stabilizing effects of sexual selection moderate the effects of drift, whereas pathogen-mediated selection accelerates the loss of functionally important genetic diversity. Natural selection enhances MHC allelic variation in larger populations, with the highest levels of diversity generated by the combined action of pathogen-mediated selection and disassortative mating. MHC-based sexual selection may help to explain how functionally important genetic variation can be maintained in populations of conservation concern. äSexual selection and the evolutionary dynamics of the major histocompa(epmc).pdf DeepDyve Pubget Overpricing