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10.1002/bdrc.21063

http://scihub22266oqcxt.onion/10.1002/bdrc.21063
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C4213238!4213238!24864023
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suck abstract from ncbi

pmid24864023      Birth+Defects+Res+C+Embryo+Today 2014 ; 102 (2): 139-58
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  • Primary Cilia in Pancreatic Development and Disease #MMPMID24864023
  • Lodh S; O?Hare EA; Zaghloul NA
  • Birth Defects Res C Embryo Today 2014[Jun]; 102 (2): 139-58 PMID24864023show ga
  • Primary cilia and their anchoring basal bodies are important regulators of a growing list of signaling pathways. Consequently, dysfunction in proteins associated with these structures results in perturbation of the development and function of a spectrum of tissue and cell types. Here, we review the role of cilia in mediating the development and function of the pancreas. We focus on ciliary regulation of major pathways involved in pancreatic development, including Shh, Wnt, TGF-?, Notch, and fibroblast growth factor. We also discuss pancreatic phenotypes associated with ciliary dysfunction, including pancreatic cysts and defects in glucose homeostasis, and explore the potential role of cilia in such defects.
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