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10.1007/s00467-014-2874-8 http://scihub22266oqcxt.onion/10.1007/s00467-014-2874-8 C4213236!4213236!25017621     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pediatr+Nephrol 2014 ; 29 (12): 2333-40 Nephropedia Template TP {{tp|p=25017621|t=2014. Minimal Change Disease: A dysregulation of the podocyte CD80-CTLA-4 Axis?|pdf=|usr=}}{{25017621}} gab.com Text Minimal Change Disease: A dysregulation of the podocyte CD80-CTLA-4 Axis JO: Pediatr Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=25017621 #FOAvip Background: Minimal Change Disease (MCD) is associated with CD80 expression in podocytes and elevated urinary CD80 excretion during active disease. We have evaluated the CTLA-4 and CD80 urinary excretion during different stages of the nephrotic syndrome in patients with MCD to test the hypothesis that the persistent increased urinary CD80 excretion in MCD in relapse is due to an ineffectual CTLA-4 response of the host to curtail the CD80 activation. Methods: 32 children with biopsy-proven MCD were studied during relapse and/or remission. 11 healthy subjects served as controls. Results: Urinary CD80 excretion was significantly increased in MCD patients in relapse when compared to MCD patients in remission (p<0.001) and controls (p<0.001). Although urinary CTLA-4 excretion was higher in MCD patients in relapse than in MCD patients in remission (p=0.01) and controls (p=0.03), no significant correlation was observed between urinary CD80 and urinary CTLA-4 in MCD patients at the time of relapse (p=0.06). At the time of remission, CD80 has decreased significantly in all patients but CTLA-4 either decreased or remained unchanged in all but five patients and no correlation was observed between urinary CD80 and CTLA-4 (p=0.7). Conclusions: Urinary CTLA-4 levels do not correlate with urinary CD80 excretion, suggesting the possibility that the CTLA4 response may be suboptimal in this disease during relapse. Twit Text FOAVip Minimal Change Disease: A dysregulation of the podocyte CD80-CTLA-4 Axis ????Pediatr Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=25017621 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25017621 #FOAvip English Wikipedia <ref>{{Cite pmid|25017621}}</ref> Minimal Change Disease: A dysregulation of the podocyte CD80-CTLA-4 Axis? #MMPMID25017621 Cara-Fuentes G; Wasserfall CH; Wang H; Johnson RJ; Garin EH Pediatr Nephrol 2014[Dec]; 29 (12): 2333-40 PMID25017621show ga Background: Minimal Change Disease (MCD) is associated with CD80 expression in podocytes and elevated urinary CD80 excretion during active disease. We have evaluated the CTLA-4 and CD80 urinary excretion during different stages of the nephrotic syndrome in patients with MCD to test the hypothesis that the persistent increased urinary CD80 excretion in MCD in relapse is due to an ineffectual CTLA-4 response of the host to curtail the CD80 activation. Methods: 32 children with biopsy-proven MCD were studied during relapse and/or remission. 11 healthy subjects served as controls. Results: Urinary CD80 excretion was significantly increased in MCD patients in relapse when compared to MCD patients in remission (p<0.001) and controls (p<0.001). Although urinary CTLA-4 excretion was higher in MCD patients in relapse than in MCD patients in remission (p=0.01) and controls (p=0.03), no significant correlation was observed between urinary CD80 and urinary CTLA-4 in MCD patients at the time of relapse (p=0.06). At the time of remission, CD80 has decreased significantly in all patients but CTLA-4 either decreased or remained unchanged in all but five patients and no correlation was observed between urinary CD80 and CTLA-4 (p=0.7). Conclusions: Urinary CTLA-4 levels do not correlate with urinary CD80 excretion, suggesting the possibility that the CTLA4 response may be suboptimal in this disease during relapse. äMinimal Change Disease: A dysregulation of the podocyte CD80-CTLA-4 Ax(epmc).pdf DeepDyve Pubget Overpricing