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10.1021/nn502596b http://scihub22266oqcxt.onion/10.1021/nn502596b C4212789!4212789 !25198246     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25198246 &cmd=llinks): Failed to open stream: HTTP request failed! 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Layer-by-layer assembled antisense DNA microsponge particles for efficient delivery of cancer therapeutics |pdf=|usr=}}{{25198246 }} gab.com Text Layer-by-layer assembled antisense DNA microsponge particles for efficient delivery of cancer therapeutics JO: ACS Nano http://www.kidney.de/pget.php?&tw=1&pmid=25198246 #FOAvip Antisense oligonucleotides can be employed as a potential approach to effectively treat cancer. However, the inherent instability and inefficient systemic delivery methods for antisense therapeutics remain major challenges to their clinical application. Here, we present a polymerized oligonucleotides (ODNs) that self-assemble during their formation through an enzymatic elongation method (rolling circle replication) to generate a composite nucleic acid/magnesium pyrophosphate sponge-like microstructure, or DNA microsponge, yielding high molecular weight nucleic acid product. In addition, this densely packed ODN microsponge structure can be further condensed to generate polyelectrolyte complexes with a favorable size for cellular uptake by displacing magnesium pyrophosphate crystals from the microsponge structure. Additional layers are applied to generate a blood-stable and multifunctional nanoparticle via the layer-by-layer (LbL) assembly technique. By taking advantage of DNA nanotechnology and LbL assembly, functionalized DNA nanostructures were utilized to provide extremely high numbers of repeated ODN copies for efficient antisense therapy. Moreover, we show that this formulation significantly improves nucleic acid drug/carrier stability during in vivo biodistribution. These polymeric ODN systems can be designed to serve as a potent means of delivering stable and large quantities of ODN therapeutics systemically for cancer treatment to tumor cells at significantly lower toxicity than traditional synthetic vectors, thus enabling a therapeutic window suitable for clinical translation. Twit Text FOAVip Layer-by-layer assembled antisense DNA microsponge particles for efficient delivery of cancer therapeutics ????ACS Nano http://www.kidney.de/pget.php?&tw=1&pmid=25198246 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25198246 #FOAvip English Wikipedia <ref>{{Cite pmid|25198246 }}</ref> Layer-by-layer assembled antisense DNA microsponge particles for efficient delivery of cancer therapeutics #MMPMID25198246 Roh YH ; Lee JB ; Shopsowitz KE ; Dreaden EC ; Morton SW ; Poon Z ; Hong J ; Yamin I ; Bonner DK ; Hammond PT ACS Nano 2014[Oct]; 8 (10 ): 9767-80 PMID25198246 show ga Antisense oligonucleotides can be employed as a potential approach to effectively treat cancer. However, the inherent instability and inefficient systemic delivery methods for antisense therapeutics remain major challenges to their clinical application. Here, we present a polymerized oligonucleotides (ODNs) that self-assemble during their formation through an enzymatic elongation method (rolling circle replication) to generate a composite nucleic acid/magnesium pyrophosphate sponge-like microstructure, or DNA microsponge, yielding high molecular weight nucleic acid product. In addition, this densely packed ODN microsponge structure can be further condensed to generate polyelectrolyte complexes with a favorable size for cellular uptake by displacing magnesium pyrophosphate crystals from the microsponge structure. Additional layers are applied to generate a blood-stable and multifunctional nanoparticle via the layer-by-layer (LbL) assembly technique. By taking advantage of DNA nanotechnology and LbL assembly, functionalized DNA nanostructures were utilized to provide extremely high numbers of repeated ODN copies for efficient antisense therapy. Moreover, we show that this formulation significantly improves nucleic acid drug/carrier stability during in vivo biodistribution. These polymeric ODN systems can be designed to serve as a potent means of delivering stable and large quantities of ODN therapeutics systemically for cancer treatment to tumor cells at significantly lower toxicity than traditional synthetic vectors, thus enabling a therapeutic window suitable for clinical translation. |*Drug Carriers [MESH] |Antineoplastic Agents/*administration & dosage [MESH] |DNA, Antisense/*chemistry [MESH]Layer-by-layer assembled antisense DNA microsponge particles for effic(epmc).pdf DeepDyve Pubget Overpricing