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10.1073/pnas.1410293111 http://scihub22266oqcxt.onion/10.1073/pnas.1410293111 C4210319!4210319!25288745     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (42): E4478-84 Nephropedia Template TP {{tp|p=25288745|t=2014. Human TLR10 is an anti-inflammatory pattern-recognition receptor |pdf=|usr=}}{{25288745}} gab.com Text Human TLR10 is an anti-inflammatory pattern-recognition receptor JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25288745 #FOAvip We demonstrate the biological role of TLR10, the only member of the Toll-like receptor (TLR)-family so far without a known function. We show that TLR10 acts as an inhibitory receptor, with suppressive effects. Blocking TLR10 by specific antibodies significantly upregulated TLR2-mediated cytokine production. Additionally, we show that individuals carrying loss-of-function SNPs in TLR10 display upregulation of TLR2-mediated cytokine production. After challenging human TLR10 transgenic mice with TLR2 ligand pam3CSK4 (Pam3Cys), less inflammation could be observed when compared with wild-type mice. Taking these data together, we show that TLR10 is the only pattern-recognition receptor within the TLR family that is able to dampen TLR2 responses, thereby suppressing immune responses through production of IL-1Ra. Twit Text FOAVip Human TLR10 is an anti-inflammatory pattern-recognition receptor ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25288745 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25288745 #FOAvip English Wikipedia <ref>{{Cite pmid|25288745}}</ref> Human TLR10 is an anti-inflammatory pattern-recognition receptor #MMPMID25288745 Oosting M; Cheng SC; Bolscher JM; Vestering-Stenger R; Plantinga TS; Verschueren IC; Arts P; Garritsen A; van Eenennaam H; Sturm P; Kullberg BJ; Hoischen A; Adema GJ; van der Meer JWM; Netea MG; Joosten LAB Proc Natl Acad Sci U S A 2014[Oct]; 111 (42): E4478-84 PMID25288745show ga We demonstrate the biological role of TLR10, the only member of the Toll-like receptor (TLR)-family so far without a known function. We show that TLR10 acts as an inhibitory receptor, with suppressive effects. Blocking TLR10 by specific antibodies significantly upregulated TLR2-mediated cytokine production. Additionally, we show that individuals carrying loss-of-function SNPs in TLR10 display upregulation of TLR2-mediated cytokine production. After challenging human TLR10 transgenic mice with TLR2 ligand pam3CSK4 (Pam3Cys), less inflammation could be observed when compared with wild-type mice. Taking these data together, we show that TLR10 is the only pattern-recognition receptor within the TLR family that is able to dampen TLR2 responses, thereby suppressing immune responses through production of IL-1Ra. äHuman TLR10 is an anti-inflammatory pattern-recognition receptor (epmc).pdf DeepDyve Pubget Overpricing