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10.1073/pnas.1405752111 http://scihub22266oqcxt.onion/10.1073/pnas.1405752111 C4210283!4210283!25294927     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25294927.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (42): E4439-48 Nephropedia Template TP {{tp|p=25294927|t=2014. Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation |pdf=|usr=}}{{25294927}} gab.com Text Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25294927 #FOAvip In mitophagy, damaged mitochondria recruit parkin to ubiquitinate proteins on the outer mitochondrial membrane, targeting mitochondria for autophagosome engulfment and degradation. However, the proteins involved in mediating autophagosome formation to degrade damaged and ubiquitinated mitochondria remain unknown. We used live cell imaging to demonstrate that optineurin is actively recruited to parkin-labeled ubiquitinated mitochondria and is stabilized by its ubiquitin binding domain. Optineurin binds the autophagosome protein LC3 (microtubule-associated protein light chain 3), and this binding recruits autophagosome assembly around damaged mitochondria. We find that the E478G optineurin mutation, causative for the neurodegenerative disease amyotrophic lateral sclerosis, disrupts autophagosome recruitment. As mutations in parkin are linked to Parkinson?s disease, this study indicates that defects in a single mitochondrial degradation pathway lead to neurodegenerative diseases with distinct pathologies. Twit Text FOAVip Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25294927 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25294927 #FOAvip English Wikipedia <ref>{{Cite pmid|25294927}}</ref> Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation #MMPMID25294927 Wong YC; Holzbaur ELF Proc Natl Acad Sci U S A 2014[Oct]; 111 (42): E4439-48 PMID25294927show ga In mitophagy, damaged mitochondria recruit parkin to ubiquitinate proteins on the outer mitochondrial membrane, targeting mitochondria for autophagosome engulfment and degradation. However, the proteins involved in mediating autophagosome formation to degrade damaged and ubiquitinated mitochondria remain unknown. We used live cell imaging to demonstrate that optineurin is actively recruited to parkin-labeled ubiquitinated mitochondria and is stabilized by its ubiquitin binding domain. Optineurin binds the autophagosome protein LC3 (microtubule-associated protein light chain 3), and this binding recruits autophagosome assembly around damaged mitochondria. We find that the E478G optineurin mutation, causative for the neurodegenerative disease amyotrophic lateral sclerosis, disrupts autophagosome recruitment. As mutations in parkin are linked to Parkinson?s disease, this study indicates that defects in a single mitochondrial degradation pathway lead to neurodegenerative diseases with distinct pathologies. äOptineurin is an autophagy receptor for damaged mitochondria in parkin(epmc).pdf DeepDyve Pubget Overpricing