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10.1021/ja5030657 http://scihub22266oqcxt.onion/10.1021/ja5030657 C4210145!4210145!24955778     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Chem+Soc 2014 ; 136 (28): 9814-7 Nephropedia Template TP {{tp|p=24955778|t=2014. Disruption of Allosteric Response as an Unprecedented Mechanism of Resistance to Antibiotics |pdf=|usr=}}{{24955778}} gab.com Text Disruption of Allosteric Response as an Unprecedented Mechanism of Resistance to Antibiotics JO: J Am Chem Soc http://www.kidney.de/pget.php?&tw=1&pmid=24955778 #FOAvip Ceftaroline, a recently approved ?-lactam antibiotic for treatment of infections by methicillin-resistant Staphylococcus aureus (MRSA), is able to inhibit penicillin-binding protein 2a (PBP2a) by triggering an allosteric conformational change that leads to the opening of the active site. The opened active site is now vulnerable to inhibition by a second molecule of ceftaroline, an event that impairs cell-wall biosynthesis and leads to bacterial death. The triggering of the allosteric effect takes place by binding of the first antibiotic molecule 60 Ĺ away from the active site of PBP2a within the core of the allosteric site. We document, by kinetic studies and by determination of three X-ray structures of the mutant variants of PBP2a that result in resistance to ceftaroline, that the effect of these clinical mutants is the disruption of the allosteric trigger in this important protein in MRSA. This is an unprecedented mechanism for antibiotic resistance. Twit Text FOAVip Disruption of Allosteric Response as an Unprecedented Mechanism of Resistance to Antibiotics ????J Am Chem Soc http://www.kidney.de/pget.php?&tw=1&pmid=24955778 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24955778 #FOAvip English Wikipedia <ref>{{Cite pmid|24955778}}</ref> Disruption of Allosteric Response as an Unprecedented Mechanism of Resistance to Antibiotics #MMPMID24955778 Fishovitz J; Rojas-Altuve A; Otero L; Dawley M; Carrasco-López C; Chang M; Hermoso JA; Mobashery S J Am Chem Soc 2014[Jul]; 136 (28): 9814-7 PMID24955778show ga Ceftaroline, a recently approved ?-lactam antibiotic for treatment of infections by methicillin-resistant Staphylococcus aureus (MRSA), is able to inhibit penicillin-binding protein 2a (PBP2a) by triggering an allosteric conformational change that leads to the opening of the active site. The opened active site is now vulnerable to inhibition by a second molecule of ceftaroline, an event that impairs cell-wall biosynthesis and leads to bacterial death. The triggering of the allosteric effect takes place by binding of the first antibiotic molecule 60 Ĺ away from the active site of PBP2a within the core of the allosteric site. We document, by kinetic studies and by determination of three X-ray structures of the mutant variants of PBP2a that result in resistance to ceftaroline, that the effect of these clinical mutants is the disruption of the allosteric trigger in this important protein in MRSA. This is an unprecedented mechanism for antibiotic resistance. äDisruption of Allosteric Response as an Unprecedented Mechanism of Res(epmc).pdf DeepDyve Pubget Overpricing