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10.1073/pnas.1416569111 http://scihub22266oqcxt.onion/10.1073/pnas.1416569111 C4210016!4210016!25246558     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (40): 14506-11 Nephropedia Template TP {{tp|p=25246558|t=2014. Enhanced natural killer-cell and T-cell responses to influenza A virus during pregnancy |pdf=|usr=}}{{25246558}} gab.com Text Enhanced natural killer-cell and T-cell responses to influenza A virus during pregnancy JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25246558 #FOAvip Pregnant women are subject to increased morbidity and mortality after influenza-virus infection. Pregnancy-induced suppression of the cellular immune system to promote fetal tolerance has been suggested as a potential mechanism. Here, we report that, whereas pregnant women indeed have decreased natural killer (NK)- and T-cell functional responses after nonspecific stimulation with phorbol 12-myristate 13-acetate and ionomycin, they have significantly increased NK- and T-cell responses to influenza virus compared with nonpregnant women. Intriguingly, these differences were present prior to influenza vaccination and were further enhanced after vaccination. Collectively, our data suggest a model in which an enhanced inflammatory response to influenza during pregnancy results in additional pathology in pregnant women, providing a potential explanation for their disproportionate morbidity and mortality. Twit Text FOAVip Enhanced natural killer-cell and T-cell responses to influenza A virus during pregnancy ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25246558 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25246558 #FOAvip English Wikipedia <ref>{{Cite pmid|25246558}}</ref> Enhanced natural killer-cell and T-cell responses to influenza A virus during pregnancy #MMPMID25246558 Kay AW; Fukuyama J; Aziz N; Dekker CL; Mackey S; Swan GE; Davis MM; Holmes S; Blish CA Proc Natl Acad Sci U S A 2014[Oct]; 111 (40): 14506-11 PMID25246558show ga Pregnant women are subject to increased morbidity and mortality after influenza-virus infection. Pregnancy-induced suppression of the cellular immune system to promote fetal tolerance has been suggested as a potential mechanism. Here, we report that, whereas pregnant women indeed have decreased natural killer (NK)- and T-cell functional responses after nonspecific stimulation with phorbol 12-myristate 13-acetate and ionomycin, they have significantly increased NK- and T-cell responses to influenza virus compared with nonpregnant women. Intriguingly, these differences were present prior to influenza vaccination and were further enhanced after vaccination. Collectively, our data suggest a model in which an enhanced inflammatory response to influenza during pregnancy results in additional pathology in pregnant women, providing a potential explanation for their disproportionate morbidity and mortality. äEnhanced natural killer-cell and T-cell responses to influenza A virus(epmc).pdf DeepDyve Pubget Overpricing