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Performance of a ?ēZn/?ēCu microgenerator in kit-based synthesis and delivery of
?ēCu Cu-ETS for PET perfusion imaging
#MMPMID24886964
Ng Y
; Lacy JL
; Fletcher JW
; Green MA
Appl Radiat Isot
2014[Sep]; 91
(?): 38-43
PMID24886964
show ga
The performance of a commercially produced (62)Zn/(62)Cu microgenerator system,
and an associated kit-based radiopharmaceutical synthesis method, was evaluated
for clinical site production of [(62)Cu]Cu-ETS (ethylglyoxal
bis(thiosemicarbazonato)copper(II)), an investigational agent for PET perfusion
imaging. Using 37 generators, containing 1.84ą0.23 GBq (62)Zn at 9:00 AM on the
day of clinical use, a total of 45 patient doses of [(62)Cu]Cu-ETS (672ą172 MBq)
were delivered without difficulty. (62)Cu elution yields were high (approximately
90%), accompanied by extremely low (62)Zn breakthrough (<0.001%).
Radiopharmaceutical preparation, from the start-of-elution to time-of-injection,
consumed less than five minutes. The (62)Zn/(62)Cu microgenerator was a
dependable source of short-lived positron-emitting (62)Cu, and the kit-based
synthesis proved to be rapid, robust, and highly reliable for "on-demand"
delivery of [(62)Cu]Cu-ETS for PET perfusion imaging.
|Copper Radioisotopes/*chemistry
[MESH]
|Head and Neck Neoplasms/diagnostic imaging
[MESH]
free
free
free
