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10.1016/j.jaci.2013.12.021 http://scihub22266oqcxt.onion/10.1016/j.jaci.2013.12.021 C4209254!4209254!24486067     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24486067&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Allergy+Clin+Immunol 2014 ; 134 (1): 204-14 Nephropedia Template TP {{tp|p=24486067|t=2014. The transcription factor Etv5 controls TH17 cell development and allergic airway inflammation |pdf=|usr=}}{{24486067}} gab.com Text The transcription factor Etv5 controls TH17 cell development and allergic airway inflammation JO: J Allergy Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24486067 #FOAvip Background: The differentiation of TH17 cells, which promote pulmonary inflammation, requires the cooperation of a network of transcription factors. Objectives: We sought to define the role of Etv5, an Ets-family transcription factor, in TH17 cell development and function. Methods: TH17 development was examined in primary mouse T cells wherein Etv5 expression was altered by retroviral transduction, small interfering RNA targeting a specific gene, and mice with a conditional deletion of Etv5 in T cells. The direct function of Etv5 on the Il17 locus was tested with chromatin immunoprecipitation and reporter assays. The house dust mite?induced allergic inflammation model was used to test the requirement for Etv5-dependent TH17 functions in vivo. Results: We identify Etv5 as a signal transducer and activator of transcription 3?induced positive regulator of TH17 development. Etv5 controls TH17 differentiation by directly promoting 0a and Il17f expression. Etv5 recruits histone-modifying enzymes to the Il17a?Il17f locus, resulting in increased active histone marks and decreased repressive histone marks. In a model of allergic airway inflammation, mice with Etv5-deficient T cells have reduced airway inflammation and IL-17A/F production in the lung and bronchoalveolar lavage fluid compared with wild-type mice, without changes in TH2 cytokine production. Conclusions: These data define signal transducer and activator of transcription 3?dependent feed-forward control of TH17 cytokine production and a novel role for Etv5 in promoting T cell?dependent airway inflammation. Twit Text FOAVip The transcription factor Etv5 controls TH17 cell development and allergic airway inflammation ????J Allergy Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24486067 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24486067 #FOAvip English Wikipedia <ref>{{Cite pmid|24486067}}</ref> The transcription factor Etv5 controls TH17 cell development and allergic airway inflammation #MMPMID24486067 Pham D; Sehra S; Sun X; Kaplan MH J Allergy Clin Immunol 2014[Jul]; 134 (1): 204-14 PMID24486067show ga Background: The differentiation of TH17 cells, which promote pulmonary inflammation, requires the cooperation of a network of transcription factors. Objectives: We sought to define the role of Etv5, an Ets-family transcription factor, in TH17 cell development and function. Methods: TH17 development was examined in primary mouse T cells wherein Etv5 expression was altered by retroviral transduction, small interfering RNA targeting a specific gene, and mice with a conditional deletion of Etv5 in T cells. The direct function of Etv5 on the Il17 locus was tested with chromatin immunoprecipitation and reporter assays. The house dust mite?induced allergic inflammation model was used to test the requirement for Etv5-dependent TH17 functions in vivo. Results: We identify Etv5 as a signal transducer and activator of transcription 3?induced positive regulator of TH17 development. Etv5 controls TH17 differentiation by directly promoting 0a and Il17f expression. Etv5 recruits histone-modifying enzymes to the Il17a?Il17f locus, resulting in increased active histone marks and decreased repressive histone marks. In a model of allergic airway inflammation, mice with Etv5-deficient T cells have reduced airway inflammation and IL-17A/F production in the lung and bronchoalveolar lavage fluid compared with wild-type mice, without changes in TH2 cytokine production. Conclusions: These data define signal transducer and activator of transcription 3?dependent feed-forward control of TH17 cytokine production and a novel role for Etv5 in promoting T cell?dependent airway inflammation. äThe transcription factor Etv5 controls TH17 cell development and aller(epmc).pdf DeepDyve Pubget Overpricing