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10.1101/cshperspect.a015297

http://scihub22266oqcxt.onion/10.1101/cshperspect.a015297
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C4208714!4208714!25368015
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suck abstract from ncbi


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pmid25368015      Cold+Spring+Harb+Perspect+Med 2014 ; 4 (11): ä
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  • Desmosomes: Regulators of Cellular Signaling and Adhesion in Epidermal Health and Disease #MMPMID25368015
  • Johnson JL; Najor NA; Green KJ
  • Cold Spring Harb Perspect Med 2014[Nov]; 4 (11): ä PMID25368015show ga
  • Desmosomes are intercellular junctions that mediate cell?cell adhesion and anchor the intermediate filament network to the plasma membrane, providing mechanical resilience to tissues such as the epidermis and heart. In addition to their critical roles in adhesion, desmosomal proteins are emerging as mediators of cell signaling important for proper cell and tissue functions. In this review we highlight what is known about desmosomal proteins regulating adhesion and signaling in healthy skin?in morphogenesis, differentiation and homeostasis, wound healing, and protection against environmental damage. We also discuss how human diseases that target desmosome molecules directly or interfere indirectly with these mechanical and signaling functions to contribute to pathogenesis.
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