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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Intellect+Disabil+Res
2014 ; 58
(10
): 940-52
Nephropedia Template TP
gab.com Text
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English Wikipedia
Consistency between research and clinical diagnoses of autism among boys and
girls with fragile X syndrome
#MMPMID24528851
Klusek J
; Martin GE
; Losh M
J Intellect Disabil Res
2014[Oct]; 58
(10
): 940-52
PMID24528851
show ga
BACKGROUND: Prior research suggests that 60-74% of males and 16-45% of females
with fragile X syndrome (FXS) meet criteria for autism spectrum disorder (ASD) in
research settings. However, relatively little is known about the rates of
clinical diagnoses in FXS and whether such diagnoses are consistent with those
performed in a research setting using gold standard diagnostic tools. METHOD:
This study explored whether boys and girls with FXS met criteria for ASD in a
research setting using the Autism Diagnostic Observation Schedule (ADOS) and the
Autism Diagnostic Interview-Revised (ADI-R), and then compared these data with
the frequency of parent-reported clinical diagnoses. We also examined child and
family characteristics as potential diagnostic predictors across settings.
Participants included 35 females and 51 males with FXS (mean age: 10 years), who
were from Eastern and Midwestern regions of the USA. RESULTS: About half of the
children met criteria for ASD on either the ADOS or ADI-R, with ASD occurring
three times more frequently in males than females (?75% vs. ?25%). In contrast,
?25% of participants of both genders had received a clinical diagnosis of ASD.
While cognitive and language skills predicted diagnostic outcome on the ADOS and
ADI-R, these skills did not predict clinical diagnoses. Executive functions
predicted clinical diagnoses, but not diagnoses per the ADOS or ADI-R.
CONCLUSIONS: ASD in FXS may be under-diagnosed in clinical/educational settings,
which raises questions regarding access to ASD-related services.
|Adolescent
[MESH]
|Child
[MESH]
|Child Development Disorders, Pervasive/*diagnosis/epidemiology
[MESH]
|Child, Preschool
[MESH]
|Comorbidity
[MESH]
|Female
[MESH]
|Fragile X Syndrome/*diagnosis/epidemiology
[MESH]