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2014 ; 87
(1043
): 20140374
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High-intensity focused ultrasound ablation: an effective and safe treatment for
secondary hypersplenism
#MMPMID25141274
Zhu J
; Zhu H
; Mei Z
; Zhang L
; Jin C
; Ran L
; Zhou K
; Yang W
Br J Radiol
2014[Nov]; 87
(1043
): 20140374
PMID25141274
show ga
OBJECTIVE: Hypersplenism is a common disease. The conventional treatment is
splenectomy and partial splenic embolization; however, both of them have high
complication rates and technical defects. Therefore, safer and more effective
techniques should be considered for the treatment of hypersplenism.
High-intensity focused ultrasound (HIFU) may provide an effective and safe way
for treatment of hypersplenism. Therefore, we conducted this study to assess the
safety and efficacy of HIFU in treatment of secondary hypersplenism. METHODS: A
total of 28 patients who suffered from secondary hypersplenism were treated with
HIFU ablation. All patients who underwent HIFU were closely followed-up over a
year. MRI scan was performed, and the spleens were observed. Blood counts and
liver function tests were also carried out. RESULTS: In the follow-up process,
the levels of white blood cells and platelets in the blood after HIFU were
significantly higher than those before HIFU, liver function also improved after
HIFU treatment. In addition, the symptoms were ameliorated significantly or even
disappeared. The MRI showed that the ablation area had turned into a non-perfused
volume, and after 12 months of HIFU ablation, the ablated area shrank evidently;
the sunken spleen formed a lobulated shape and the splenic volume decreased.
CONCLUSION: HIFU ablation is a safe, effective and non-invasive approach for
secondary hypersplenism. ADVANCES IN KNOWLEDGE: For the first time we used HIFU
ablation to treat secondary hypersplenism. It not only expands indications of
HIFU but also provides better choice for the treatment of secondary
hypersplenism.
free
free
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