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10.1117/1.JBO.19.10.105009 http://scihub22266oqcxt.onion/10.1117/1.JBO.19.10.105009 C4206751!4206751 !25341069     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25341069 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Biomed+Opt 2014 ; 19 (10 ): 105009 Nephropedia Template TP {{tp|p=25341069 |t=2014. Photochemical internalization-mediated nonviral gene transfection: polyamine core-shell nanoparticles as gene carrier |pdf=|usr=}}{{25341069 }} gab.com Text Photochemical internalization-mediated nonviral gene transfection: polyamine core-shell nanoparticles as gene carrier JO: J Biomed Opt http://www.kidney.de/pget.php?&tw=1&pmid=25341069 #FOAvip The overall objective of the research was to investigate the utility of photochemical internalization (PCI) for the enhanced nonviral transfection of genes into glioma cells. The PCI-mediated introduction of the tumor suppressor gene phosphatase and tensin homolog (PTEN) or the cytosine deaminase (CD) pro-drug activating gene into U87 or U251 glioma cell monolayers and multicell tumor spheroids were evaluated. In the study reported here, polyamine-DNA gene polyplexes were encapsulated in a nanoparticle (NP) with an acid degradable polyketal outer shell. These NP synthetically mimic the roles of viral capsid and envelope, which transport and release the gene, respectively. The effects of PCI-mediated suppressor and suicide genes transfection efficiency employing either ?naked? polyplex cores alone or as NP-shelled cores were compared. PCI was performed with the photosensitizer AlPcS 2a and ?=670-nm laser irradiance. The results clearly demonstrated that the PCI can enhance the delivery of both the PTEN or CD genes in human glioma cell monolayers and multicell tumor spheroids. The transfection efficiency, as measured by cell survival and inhibition of spheroid growth, was found to be significantly greater at suboptimal light and DNA levels for shelled NPs compared with polyamine-DNA polyplexes alone. Twit Text FOAVip Photochemical internalization-mediated nonviral gene transfection: polyamine core-shell nanoparticles as gene carrier ????J Biomed Opt http://www.kidney.de/pget.php?&tw=1&pmid=25341069 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25341069 #FOAvip English Wikipedia <ref>{{Cite pmid|25341069 }}</ref> Photochemical internalization-mediated nonviral gene transfection: polyamine core-shell nanoparticles as gene carrier #MMPMID25341069 Zamora G ; Wang F ; Sun CH ; Trinidad A ; Kwon YJ ; Cho SK ; Berg K ; Madsen SJ ; Hirschberg H J Biomed Opt 2014[]; 19 (10 ): 105009 PMID25341069 show ga The overall objective of the research was to investigate the utility of photochemical internalization (PCI) for the enhanced nonviral transfection of genes into glioma cells. The PCI-mediated introduction of the tumor suppressor gene phosphatase and tensin homolog (PTEN) or the cytosine deaminase (CD) pro-drug activating gene into U87 or U251 glioma cell monolayers and multicell tumor spheroids were evaluated. In the study reported here, polyamine-DNA gene polyplexes were encapsulated in a nanoparticle (NP) with an acid degradable polyketal outer shell. These NP synthetically mimic the roles of viral capsid and envelope, which transport and release the gene, respectively. The effects of PCI-mediated suppressor and suicide genes transfection efficiency employing either ?naked? polyplex cores alone or as NP-shelled cores were compared. PCI was performed with the photosensitizer AlPcS 2a and ?=670-nm laser irradiance. The results clearly demonstrated that the PCI can enhance the delivery of both the PTEN or CD genes in human glioma cell monolayers and multicell tumor spheroids. The transfection efficiency, as measured by cell survival and inhibition of spheroid growth, was found to be significantly greater at suboptimal light and DNA levels for shelled NPs compared with polyamine-DNA polyplexes alone. |Cell Line, Tumor [MESH] |Cell Proliferation/drug effects/genetics [MESH] |Cell Survival/drug effects/genetics [MESH] |Cytosine Deaminase/genetics/metabolism/pharmacology [MESH] |Drug Carriers/*chemistry/pharmacology/toxicity [MESH] |Genetic Therapy [MESH] |Humans [MESH] |Nanoparticles/*chemistry/toxicity [MESH] |PTEN Phosphohydrolase/genetics/metabolism/pharmacology [MESH] |Photochemotherapy [MESH] |Photosensitizing Agents/*chemistry/pharmacology/toxicity [MESH] |Polyamines/*chemistry/pharmacology/toxicity [MESH] |Spheroids, Cellular [MESH]Photochemical internalization-mediated nonviral gene transfection: pol(epmc).pdf DeepDyve Pubget Overpricing