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10.1016/j.cell.2014.09.020 http://scihub22266oqcxt.onion/10.1016/j.cell.2014.09.020 C4206218!4206218 !25303526     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25303526 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell 2014 ; 159 (2 ): 295-305 Nephropedia Template TP {{tp|p=25303526 |t=2014. Oxytocin modulates female sociosexual behavior through a specific class of prefrontal cortical interneurons |pdf=|usr=}}{{25303526 }} gab.com Text Oxytocin modulates female sociosexual behavior through a specific class of prefrontal cortical interneurons JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=25303526 #FOAvip Human imaging studies have revealed that intranasal administration of the "prosocial" hormone oxytocin (OT) activates the frontal cortex, and this action of OT correlates with enhanced brain function in autism. Here, we report the discovery of a population of somatostatin (Sst)-positive, regular spiking interneurons that express the oxytocin receptor (OxtrINs). Silencing of OxtrINs in the medial prefrontal cortex (mPFC) of female mice resulted in loss of social interest in male mice specifically during the sexually receptive phase of the estrous cycle. This sociosexual deficit was also present in mice in which the Oxtr gene was conditionally deleted from the mPFC and in control mice infused with an Oxtr antagonist. Our data demonstrate a gender-, cell type-, and state-specific role for OT/Oxtr signaling in the mPFC and identify a latent cortical circuit element that may modulate other complex social behaviors in response to OT. Twit Text FOAVip Oxytocin modulates female sociosexual behavior through a specific class of prefrontal cortical interneurons ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=25303526 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25303526 #FOAvip English Wikipedia <ref>{{Cite pmid|25303526 }}</ref> Oxytocin modulates female sociosexual behavior through a specific class of prefrontal cortical interneurons #MMPMID25303526 Nakajima M ; Görlich A ; Heintz N Cell 2014[Oct]; 159 (2 ): 295-305 PMID25303526 show ga Human imaging studies have revealed that intranasal administration of the "prosocial" hormone oxytocin (OT) activates the frontal cortex, and this action of OT correlates with enhanced brain function in autism. Here, we report the discovery of a population of somatostatin (Sst)-positive, regular spiking interneurons that express the oxytocin receptor (OxtrINs). Silencing of OxtrINs in the medial prefrontal cortex (mPFC) of female mice resulted in loss of social interest in male mice specifically during the sexually receptive phase of the estrous cycle. This sociosexual deficit was also present in mice in which the Oxtr gene was conditionally deleted from the mPFC and in control mice infused with an Oxtr antagonist. Our data demonstrate a gender-, cell type-, and state-specific role for OT/Oxtr signaling in the mPFC and identify a latent cortical circuit element that may modulate other complex social behaviors in response to OT. |*Sexual Behavior, Animal [MESH] |Animals [MESH] |Estrous Cycle [MESH] |Female [MESH] |Interneurons/*metabolism [MESH] |Male [MESH] |Mice [MESH] |Oxytocin/metabolism [MESH] |Prefrontal Cortex/cytology/*metabolism [MESH] |Receptors, Oxytocin/*metabolism [MESH] |Sex Characteristics [MESH]Oxytocin modulates female sociosexual behavior through a specific clas(epmc).pdf DeepDyve Pubget Overpricing