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10.4161/sgtp.29260 http://scihub22266oqcxt.onion/10.4161/sgtp.29260 C4205150!4205150!24911990     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Small+GTPases 2014 ; 5 (ä): ä Nephropedia Template TP {{tp|p=24911990|t=2014. Novel role of Cdc42 and RalA GTPases in TNF-? mediated secretion of CCL2 |pdf=|usr=}}{{24911990}} gab.com Text Novel role of Cdc42 and RalA GTPases in TNF- mediated secretion of CCL2 JO: Small GTPases http://www.kidney.de/pget.php?&tw=1&pmid=24911990 #FOAvip Transendothelial migration of autoreactive leukocytes into peripheral nerves is an early pathological hallmark of acute inflammatory demyelinating polyneuropathy (AIDP), a North American and European variant of Guillain-Barré Syndrome. Whereas the clinical management of AIDP is currently limited to non-selective immune modulating therapies, recent experimental studies support selective targeting of leukocyte trafficking as a promising alternative therapeutic strategy. Here, using a combination of targeted siRNA knockdown and pharmacological inhibitors, we report a novel role of both Cdc42 and RalA GTPases in facilitating TNF-? mediated CCL2 trafficking and release from immortalized rat peripheral nerve microvascular endoneurial endothelial cells. These findings raise interest in Cdc42 and RalA GTPases as potential therapeutic targets for the management of autoimmune inflammatory peripheral nerve disease. Twit Text FOAVip Novel role of Cdc42 and RalA GTPases in TNF- mediated secretion of CCL2 ????Small GTPases http://www.kidney.de/pget.php?&tw=1&pmid=24911990 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24911990 #FOAvip English Wikipedia <ref>{{Cite pmid|24911990}}</ref> Novel role of Cdc42 and RalA GTPases in TNF-? mediated secretion of CCL2 #MMPMID24911990 Langert KA; Pervan CL; Stubbs, Jr EB Small GTPases 2014[]; 5 (ä): ä PMID24911990show ga Transendothelial migration of autoreactive leukocytes into peripheral nerves is an early pathological hallmark of acute inflammatory demyelinating polyneuropathy (AIDP), a North American and European variant of Guillain-Barré Syndrome. Whereas the clinical management of AIDP is currently limited to non-selective immune modulating therapies, recent experimental studies support selective targeting of leukocyte trafficking as a promising alternative therapeutic strategy. Here, using a combination of targeted siRNA knockdown and pharmacological inhibitors, we report a novel role of both Cdc42 and RalA GTPases in facilitating TNF-? mediated CCL2 trafficking and release from immortalized rat peripheral nerve microvascular endoneurial endothelial cells. These findings raise interest in Cdc42 and RalA GTPases as potential therapeutic targets for the management of autoimmune inflammatory peripheral nerve disease. äNovel role of Cdc42 and RalA GTPases in TNF-? mediated secretion of CC(epmc).pdf DeepDyve Pubget Overpricing