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10.1084/jem.20132528 http://scihub22266oqcxt.onion/10.1084/jem.20132528 C4203954!4203954 !25311507     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25311507 &cmd=llinks): Failed to open stream: HTTP request failed! 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Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses |pdf=|usr=}}{{25311507 }} gab.com Text Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=25311507 #FOAvip Fibroblast-like cells of secondary lymphoid organs (SLO) are important for tissue architecture. In addition, they regulate lymphocyte compartmentalization through the secretion of chemokines, and participate in the orchestration of appropriate cell-cell interactions required for adaptive immunity. Here, we provide data demonstrating the functional importance of SLO fibroblasts during Notch-mediated lineage specification and immune response. Genetic ablation of the Notch ligand Delta-like (DL)1 identified splenic fibroblasts rather than hematopoietic or endothelial cells as niche cells, allowing Notch 2-driven differentiation of marginal zone B cells and of Esam(+) dendritic cells. Moreover, conditional inactivation of DL4 in lymph node fibroblasts resulted in impaired follicular helper T cell differentiation and, consequently, in reduced numbers of germinal center B cells and absence of high-affinity antibodies. Our data demonstrate previously unknown roles for DL ligand-expressing fibroblasts in SLO niches as drivers of multiple Notch-mediated immune differentiation processes. Twit Text FOAVip Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=25311507 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25311507 #FOAvip English Wikipedia <ref>{{Cite pmid|25311507 }}</ref> Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses #MMPMID25311507 Fasnacht N ; Huang HY ; Koch U ; Favre S ; Auderset F ; Chai Q ; Onder L ; Kallert S ; Pinschewer DD ; MacDonald HR ; Tacchini-Cottier F ; Ludewig B ; Luther SA ; Radtke F J Exp Med 2014[Oct]; 211 (11 ): 2265-79 PMID25311507 show ga Fibroblast-like cells of secondary lymphoid organs (SLO) are important for tissue architecture. In addition, they regulate lymphocyte compartmentalization through the secretion of chemokines, and participate in the orchestration of appropriate cell-cell interactions required for adaptive immunity. Here, we provide data demonstrating the functional importance of SLO fibroblasts during Notch-mediated lineage specification and immune response. Genetic ablation of the Notch ligand Delta-like (DL)1 identified splenic fibroblasts rather than hematopoietic or endothelial cells as niche cells, allowing Notch 2-driven differentiation of marginal zone B cells and of Esam(+) dendritic cells. Moreover, conditional inactivation of DL4 in lymph node fibroblasts resulted in impaired follicular helper T cell differentiation and, consequently, in reduced numbers of germinal center B cells and absence of high-affinity antibodies. Our data demonstrate previously unknown roles for DL ligand-expressing fibroblasts in SLO niches as drivers of multiple Notch-mediated immune differentiation processes. |*Immunity [MESH] |Adaptor Proteins, Signal Transducing [MESH] |Animals [MESH] |B-Lymphocytes/cytology/immunology/metabolism [MESH] |Biomarkers/metabolism [MESH] |Calcium-Binding Proteins [MESH] |Cell Adhesion Molecules/metabolism [MESH] |Cell Differentiation [MESH] |Cellular Microenvironment/*immunology [MESH] |Chemokine CCL19/metabolism [MESH] |Dendritic Cells/immunology/metabolism [MESH] |Fibroblasts/*metabolism [MESH] |Germinal Center/immunology/metabolism [MESH] |Immunophenotyping [MESH] |Intercellular Signaling Peptides and Proteins/genetics/metabolism [MESH] |Intracellular Signaling Peptides and Proteins/metabolism [MESH] |Lymph Nodes/immunology/metabolism [MESH] |Lymphoid Tissue/*immunology/*metabolism [MESH] |Membrane Proteins/metabolism [MESH] |Mice [MESH] |Mice, Transgenic [MESH] |Phenotype [MESH] |Receptors, Notch/*metabolism [MESH] |Spleen/immunology/metabolism [MESH] |Stromal Cells/metabolism [MESH]Specific fibroblastic niches in secondary lymphoid organs orchestrate (epmc).pdf DeepDyve Pubget Overpricing