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10.1084/jem.20130795

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C4203943!4203943!25288397
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suck abstract from ncbi


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pmid25288397      J+Exp+Med 2014 ; 211 (11): 2199-212
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  • The AP-1 transcription factor Fra1 inhibits follicular B cell differentiation into plasma cells #MMPMID25288397
  • Grötsch B; Brachs S; Lang C; Luther J; Derer A; Schlötzer-Schrehardt U; Bozec A; Fillatreau S; Berberich I; Hobeika E; Reth M; Wagner EF; Schett G; Mielenz D; David JP
  • J Exp Med 2014[Oct]; 211 (11): 2199-212 PMID25288397show ga
  • Grötsch et al. find that the AP-1 transcription factor Fra-1 limits the generation of antibody-producing plasma cells. Absence of Fra1 in B cells results in abnormally high numbers of plasma cells and increased antibody responses after vaccination.
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