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10.1002/cpe.3274

http://scihub22266oqcxt.onion/10.1002/cpe.3274
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C4203657!4203657!25342933
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suck abstract from ncbi


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pmid25342933      Concurr+Comput 2014 ; 26 (13): 2266-79
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  • Experiences Building Globus Genomics: A Next-Generation Sequencing Analysis Service using Galaxy, Globus, and Amazon Web Services #MMPMID25342933
  • Madduri RK; Sulakhe D; Lacinski L; Liu B; Rodriguez A; Chard K; Dave UJ; Foster IT
  • Concurr Comput 2014[Sep]; 26 (13): 2266-79 PMID25342933show ga
  • We describe Globus Genomics, a system that we have developed for rapid analysis of large quantities of next-generation sequencing (NGS) genomic data. This system achieves a high degree of end-to-end automation that encompasses every stage of data analysis including initial data retrieval from remote sequencing centers or storage (via the Globus file transfer system); specification, configuration, and reuse of multi-step processing pipelines (via the Galaxy workflow system); creation of custom Amazon Machine Images and on-demand resource acquisition via a specialized elastic provisioner (on Amazon EC2); and efficient scheduling of these pipelines over many processors (via the HTCondor scheduler). The system allows biomedical researchers to perform rapid analysis of large NGS datasets in a fully automated manner, without software installation or a need for any local computing infrastructure. We report performance and cost results for some representative workloads.
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