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10.4161/auto.28919 http://scihub22266oqcxt.onion/10.4161/auto.28919 C4203557!4203557!24904996     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24904996&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Autophagy 2014 ; 10 (7): 1335-7 Nephropedia Template TP {{tp|p=24904996|t=2014. Acetyl-coenzyme A: A metabolic master regulator of autophagy and longevity |pdf=|usr=}}{{24904996}} gab.com Text Acetyl-coenzyme A: A metabolic master regulator of autophagy and longevity JO: Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=24904996 #FOAvip As the major lysosomal degradation pathway, autophagy represents the guardian of cellular homeostasis, removing damaged and potentially harmful material and replenishing energy reserves in conditions of starvation. Given its vast physiological importance, autophagy is crucially involved in the process of aging and associated pathologies. Although the regulation of autophagy strongly depends on nutrient availability, specific metabolites that modulate autophagic responses are poorly described. Recently, we revealed nucleo-cytosolic acetyl-coenzyme A (AcCoA) as a phylogenetically conserved inhibitor of starvation-induced and age-associated autophagy. AcCoA is the sole acetyl-group donor for protein acetylation, explaining why pharmacological or genetic manipulations that modify the concentrations of nucleo-cytosolic AcCoA directly affect the levels of protein acetylation. The acetylation of histones and cytosolic proteins inversely correlates with the rate of autophagy in yeast and mammalian cells, respectively, despite the fact that the routes of de novo AcCoA synthesis differ across phyla. Thus, we propose nucleo-cytosolic AcCoA to act as a conserved metabolic rheostat, linking the cellular metabolic state to the regulation of autophagy via effects on protein acetylation. Twit Text FOAVip Acetyl-coenzyme A: A metabolic master regulator of autophagy and longevity ????Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=24904996 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24904996 #FOAvip English Wikipedia <ref>{{Cite pmid|24904996}}</ref> Acetyl-coenzyme A: A metabolic master regulator of autophagy and longevity #MMPMID24904996 Schroeder S; Pendl T; Zimmermann A; Eisenberg T; Carmona-Gutierrez D; Ruckenstuhl C; Mariño G; Pietrocola F; Harger A; Magnes C; Sinner F; Pieber TR; Dengjel J; Sigrist SJ; Kroemer G; Madeo F Autophagy 2014[Jul]; 10 (7): 1335-7 PMID24904996show ga As the major lysosomal degradation pathway, autophagy represents the guardian of cellular homeostasis, removing damaged and potentially harmful material and replenishing energy reserves in conditions of starvation. Given its vast physiological importance, autophagy is crucially involved in the process of aging and associated pathologies. Although the regulation of autophagy strongly depends on nutrient availability, specific metabolites that modulate autophagic responses are poorly described. Recently, we revealed nucleo-cytosolic acetyl-coenzyme A (AcCoA) as a phylogenetically conserved inhibitor of starvation-induced and age-associated autophagy. AcCoA is the sole acetyl-group donor for protein acetylation, explaining why pharmacological or genetic manipulations that modify the concentrations of nucleo-cytosolic AcCoA directly affect the levels of protein acetylation. The acetylation of histones and cytosolic proteins inversely correlates with the rate of autophagy in yeast and mammalian cells, respectively, despite the fact that the routes of de novo AcCoA synthesis differ across phyla. Thus, we propose nucleo-cytosolic AcCoA to act as a conserved metabolic rheostat, linking the cellular metabolic state to the regulation of autophagy via effects on protein acetylation. äAcetyl-coenzyme A: A metabolic master regulator of autophagy and longe(epmc).pdf DeepDyve Pubget Overpricing