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10.4161/auto.28678 http://scihub22266oqcxt.onion/10.4161/auto.28678 C4203545!4203545!24813622     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Autophagy 2014 ; 10 (7): 1167-78 Nephropedia Template TP {{tp|p=24813622|t=2014. Autophagy plays an important role in the containment of HIV-1 in nonprogressor-infected patients |pdf=|usr=}}{{24813622}} gab.com Text Autophagy plays an important role in the containment of HIV-1 in nonprogressor-infected patients JO: Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=24813622 #FOAvip Recent in vitro studies have suggested that autophagy may play a role in both HIV-1 replication and disease progression. In this study we investigated whether autophagy protects the small proportion of HIV-1 infected individuals who remain clinically stable for years in the absence of antiretroviral therapy, these named long-term nonprogressors (LTNP) and elite controllers (EC). We found that peripheral blood mononuclear cells (PBMC) of the HIV-1 controllers present a significantly higher amount of autophagic vesicles associated with an increased expression of autophagic markers with respect to normal progressors. Of note, ex vivo treatment of PBMC from the HIV-1 controllers with the MTOR inhibitor rapamycin results in a more efficient autophagic response, leading to a reduced viral production. These data lead us to propose that autophagy contributes to limiting viral pathogenesis in HIV-1 controllers by targeting viral components for degradation. Twit Text FOAVip Autophagy plays an important role in the containment of HIV-1 in nonprogressor-infected patients ????Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=24813622 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24813622 #FOAvip English Wikipedia <ref>{{Cite pmid|24813622}}</ref> Autophagy plays an important role in the containment of HIV-1 in nonprogressor-infected patients #MMPMID24813622 Nardacci R; Amendola A; Ciccosanti F; Corazzari M; Esposito V; Vlassi C; Taibi C; Fimia GM; Del Nonno F; Ippolito G; D?Offizi G; Piacentini M Autophagy 2014[Jul]; 10 (7): 1167-78 PMID24813622show ga Recent in vitro studies have suggested that autophagy may play a role in both HIV-1 replication and disease progression. In this study we investigated whether autophagy protects the small proportion of HIV-1 infected individuals who remain clinically stable for years in the absence of antiretroviral therapy, these named long-term nonprogressors (LTNP) and elite controllers (EC). We found that peripheral blood mononuclear cells (PBMC) of the HIV-1 controllers present a significantly higher amount of autophagic vesicles associated with an increased expression of autophagic markers with respect to normal progressors. Of note, ex vivo treatment of PBMC from the HIV-1 controllers with the MTOR inhibitor rapamycin results in a more efficient autophagic response, leading to a reduced viral production. These data lead us to propose that autophagy contributes to limiting viral pathogenesis in HIV-1 controllers by targeting viral components for degradation. äAutophagy plays an important role in the containment of HIV-1 in nonpr(epmc).pdf DeepDyve Pubget Overpricing