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10.1038/ncomms6218 http://scihub22266oqcxt.onion/10.1038/ncomms6218 C4203416!4203416!25323535     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2014 ; 5 (ä): 5218 Nephropedia Template TP {{tp|p=25323535|t=2014. LIF negatively regulates tumor suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers |pdf=|usr=}}{{25323535}} gab.com Text LIF negatively regulates tumor suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25323535 #FOAvip Leukemia inhibitory factor (LIF) has been recently identified as a p53 target gene, which mediates the role of p53 in maternal implantation under normal physiological conditions. Here, we report that LIF is a negative regulator of p53; LIF downregulates p53 protein levels and function in human colorectal cancer (CRC) cells. The downregulation of p53 by LIF is mediated by the activation of Stat3, which transcriptionally induces ID1. ID1 upregulates MDM2, a key negative regulator of p53, and promotes p53 protein degradation. LIF is overexpressed in a large percentage of CRCs. LIF overexpression promotes cellular resistance towards chemotherapeutic agents in cultured CRC cells and colorectal xenograft tumors in a largely p53-dependent manner. Overexpression of LIF is associated with a poor prognosis in CRC patients. Taken together, LIF is a novel negative regulator of p53, overexpression of LIF is an important mechanism for the attenuation of p53, which promotes chemoresistance in CRCs. Twit Text FOAVip LIF negatively regulates tumor suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25323535 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25323535 #FOAvip English Wikipedia <ref>{{Cite pmid|25323535}}</ref> LIF negatively regulates tumor suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers #MMPMID25323535 Yu H; Yue X; Zhao Y; Li X; Wu L; Zhang C; Liu Z; Lin K; Xu-Monette ZY; Young KH; Liu J; Shen Z; Feng Z; Hu W Nat Commun 2014[]; 5 (ä): 5218 PMID25323535show ga Leukemia inhibitory factor (LIF) has been recently identified as a p53 target gene, which mediates the role of p53 in maternal implantation under normal physiological conditions. Here, we report that LIF is a negative regulator of p53; LIF downregulates p53 protein levels and function in human colorectal cancer (CRC) cells. The downregulation of p53 by LIF is mediated by the activation of Stat3, which transcriptionally induces ID1. ID1 upregulates MDM2, a key negative regulator of p53, and promotes p53 protein degradation. LIF is overexpressed in a large percentage of CRCs. LIF overexpression promotes cellular resistance towards chemotherapeutic agents in cultured CRC cells and colorectal xenograft tumors in a largely p53-dependent manner. Overexpression of LIF is associated with a poor prognosis in CRC patients. Taken together, LIF is a novel negative regulator of p53, overexpression of LIF is an important mechanism for the attenuation of p53, which promotes chemoresistance in CRCs. äLIF negatively regulates tumor suppressor p53 through Stat3/ID1/MDM2 i(epmc).pdf DeepDyve Pubget Overpricing