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10.1089/ars.2013.5785 http://scihub22266oqcxt.onion/10.1089/ars.2013.5785 C4202910!4202910!24350610     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Antioxid+Redox+Signal 2014 ; 21 (13): 1926-42 Nephropedia Template TP {{tp|p=24350610|t=2014. Role of Reactive Oxygen Species in Neonatal Pulmonary Vascular Disease |pdf=|usr=}}{{24350610}} gab.com Text Role of Reactive Oxygen Species in Neonatal Pulmonary Vascular Disease JO: Antioxid Redox Signal http://www.kidney.de/pget.php?&tw=1&pmid=24350610 #FOAvip Significance: Abnormal lung development in the perinatal period can result in severe neonatal complications, including persistent pulmonary hypertension (PH) of the newborn and bronchopulmonary dysplasia. Reactive oxygen species (ROS) play a substantive role in the development of PH associated with these diseases. ROS impair the normal pulmonary artery (PA) relaxation in response to vasodilators, and ROS are also implicated in pulmonary arterial remodeling, both of which can increase the severity of PH. Recent Advances: PA ROS levels are elevated when endogenous ROS-generating enzymes are activated and/or when endogenous ROS scavengers are inactivated. Animal models have provided valuable insights into ROS generators and scavengers that are dysregulated in different forms of neonatal PH, thus identifying potential therapeutic targets. Critical Issues: General antioxidant therapy has proved ineffective in reversing PH, suggesting that it is necessary to target specific signaling pathways for successful therapy. Future Directions: Development of novel selective pharmacologic inhibitors along with nonantioxidant therapies may improve the treatment outcomes of patients with PH, while further investigation of the underlying mechanisms may enable earlier detection of the disease. Antioxid. Redox Signal. 21, 1926?1942. Twit Text FOAVip Role of Reactive Oxygen Species in Neonatal Pulmonary Vascular Disease ????Antioxid Redox Signal http://www.kidney.de/pget.php?&tw=1&pmid=24350610 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24350610 #FOAvip English Wikipedia <ref>{{Cite pmid|24350610}}</ref> Role of Reactive Oxygen Species in Neonatal Pulmonary Vascular Disease #MMPMID24350610 Wedgwood S; Steinhorn RH Antioxid Redox Signal 2014[Nov]; 21 (13): 1926-42 PMID24350610show ga Significance: Abnormal lung development in the perinatal period can result in severe neonatal complications, including persistent pulmonary hypertension (PH) of the newborn and bronchopulmonary dysplasia. Reactive oxygen species (ROS) play a substantive role in the development of PH associated with these diseases. ROS impair the normal pulmonary artery (PA) relaxation in response to vasodilators, and ROS are also implicated in pulmonary arterial remodeling, both of which can increase the severity of PH. Recent Advances: PA ROS levels are elevated when endogenous ROS-generating enzymes are activated and/or when endogenous ROS scavengers are inactivated. Animal models have provided valuable insights into ROS generators and scavengers that are dysregulated in different forms of neonatal PH, thus identifying potential therapeutic targets. Critical Issues: General antioxidant therapy has proved ineffective in reversing PH, suggesting that it is necessary to target specific signaling pathways for successful therapy. Future Directions: Development of novel selective pharmacologic inhibitors along with nonantioxidant therapies may improve the treatment outcomes of patients with PH, while further investigation of the underlying mechanisms may enable earlier detection of the disease. Antioxid. Redox Signal. 21, 1926?1942. äRole of Reactive Oxygen Species in Neonatal Pulmonary Vascular Disease(epmc).pdf DeepDyve Pubget Overpricing